UniversitÉ´de Rouen

Produits Chimiques Auxiliaires Et De Synthese

Sidem Pharma Sa

Guillaume Tauvel

Gérard Coquerel

Gerard Coquerel

Jean-Marie Schneider

Avraham Cohen

Suzy Charbit

François Schutze

Marie-Noëlle Petit

Snella Chouippe

Stéphane Bernad

Marie-Noelle Petit

A precursor phase of the magnesium tetrahydrate salt of an omeprazole enantiomer, and also processes for preparing it and its use for the preparation of the magnesium tetrahydrate salt are described. Crystals of the magnesium tetrahydrate salt thus obtained, and their uses, especially in the synthesis of the dihydrate form A of the magnesium salt of the enantiomer or as medicament are also disclosed.

Precursor phase and use thereof for preparing the magnesium tetrahydrate salt of an omeprazole enantiomer

The invention relates to conglomerates of tenatoprazole potassium salts of the following general formula (I), that consist of an equimolar mixture of enantiomers having R and S configurations and capable of crystallization in the form of a conglomerate, wherein said salts are selected from tenatoprazole dehydrated potassium salt, tenatoprazole potassium dimethanolate, tenatoprazole potassium diethanolate and tenatoprazole potassium ethylene-glycolate. The invention also relates to a pharmaceutical composition containing such salt, and to the use of said salt. 

Conglomerates of tenatoprazole potassium salts

The present invention relates to the resolution by preferential crystallization of potassium salts of racemic omeprazole which is a solvate of ethanol and/or of ethylene glycol, which consists in converting the omeprazole to the potassium salt in the form of a solvate or of a mixture of these solvates in the presence of an excess of inorganic base which is a source of potassium, the said potassium salts existing in the form of conglomerates, and in then resolving the said conglomerates, independently or simultaneously, by preferential crystallization in order to separate the two (S) and (R) enantiomers of these potassium salts of omeprazole.

Method for resolving omeprazole salts

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Rouen, France

Guillaume Tauvel