The United States of America, as Represented by the Secretary, Department of Health and Human Services

Institute for Research in Biomedicine

Dartmouth College

Guillaume Stewart-Jones

Baoshan Zhang

Yongping Yang

Michael Gordon Joyce

Peter D Kwong

Ivelin Georgiev

Gwo-Yu Chuang

Aliaksandr Druz

Marie Pancera

Tongqing Zhou

Mallika Sastry

Antonio Lanzavecchia

Davide Corti

Barney S Graham

John R Mascola

Wing-Pui Kong

Yaroslav Tsybovsky

Man Chen

Li Ou

Jason Gorman

Cinque Soto

Paul Thomas

Peter L Collins

Ursula J Buchholz

Jason Scott McLellan

John Mascola

Ulrich Baxa

Masaru Kanekiyo

Cheng Cheng

Jeffrey C Boyington

Gilad Ofek

Kai Xu

Joseph Van Galen

Lei Chen

Priyamvada Acharya

Rita Chen

Emily Rundlet

Sanjay Srivatsan

Rebecca M Lynch

Wing-pui Kong

Rebecca Loomis

Jason S Mclellan

Ivelin Stefanov Georgiev

Rebecca Lynch

Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

Prefusion PIV F immunogens and their use

Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

Prefusion RSV F proteins and their use

Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

Recombinant metapneumovirus f proteins and their use

HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Recombinant HIV-1 envelope proteins and their use

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.

Nipah virus immunogens and their use

Recombinant metapneumovirus F proteins and their use

Substitutions-modified prefusion RSV F proteins and their use

Growing community of inventors

Bethesda, MD, United States of America

Guillaume Stewart-Jones