Imv Technologies

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Grenoble Alpes

Swissgenetics

Centre National De La Recherche Scientifique-cnrs

Institut National De La Sante Et De La Recherche Medicale (inserm)

Centre Hospitalier Universitaire Grenoble Alpes

Guillaume Martinez

Eric Schmitt

Christophe Arnoult

Jessica Escoffier

Pierre Ray

The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel. The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument. Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

Method for increasing the lifespan and motility of animal sperm using an inhibitor of Slo3 potassium channel

The invention relates to a La-1-like peptide agent that increases sperm motility. It is non-toxic and it may be used to treat male infertility in humans, and also to increase fertility in animals. It may be used in artificial reproductive techniques such as in vitro fertilisation (IVF), including intra-cytoplasmic sperm injection (ICSI). The La-1 like peptide agent may also be used in artificial insemination techniques such as intra-cytoplasmic uterine injection (IUI).

Use of La1-like peptide isolated from maurus palmatus venom as an activator of sperm motility in mammals

Growing community of inventors

Grenoble, France

Guillaume Martinez