Safran Aircraft Engines

Advanced Biodesign

Guillaume Martin

Ismail Ceylan

Marie Mineur-Panigeon

Céline Jeanne Marcillaud

Gerry Quash

Mileidys Perez-Alea

Norman Bruno André Jodet

Kevin Morgane Lemarchand

Serge Alain Fargeas

Laurent Soulat

Marc Soisson

Valéry Piaton

Guy Fournet

Gérard Quash

Milleidys Perez-Alea

Axelle Berrou

Mileidys Perez

The invention relates to a specific substrate on an ALDH isoenzyme, to a composition comprising at least one such substrate, to a diagnostic marker comprising such a substrate, and to the uses thereof and associated methods.

Specific substrate of an ALDH isoenzyme

A flow-straightener vane of a bypass turbomachine includes a plurality of vane sections stacked radially with respect to a longitudinal axis (X) along a stacking line (L) between a root end and a tip end. Each vane section has a pressure-face surface and a suction-face surface extending axially between an upstream leading edge and a downstream trailing edge. Between the leading and trailing edges of each vane section there is formed a profile chord (CA) the length of which is substantially constant between the tip end and the root end, and the stacking line (L) exhibits a curvature in a plane passing more or less through the axis (X) and through the stacking line (L), situated in the vicinity of the tip end and oriented from downstream towards upstream.

Turbomachine fan flow-straightener vane, turbomachine assembly comprising such a vane and turbomachine equipped with said vane or said assembly

The present invention concerns an ex vivo method for the monitoring of apoptosis which is based on the detection of free gamma-glutamyl-L-epsilon-Lysine (GGEL) in a biological sample of a subject with a monoclonal antibody specific to GGEL. The invention also relates to the monoclonal antibody specific to GGEL, as well as to diagnostic kits containing such a ligand.

Monoclonal antibody specific for gamma-glutamyl-l-epsilon-lysine for the monitoring of apoptosis

The manufacture of a metal turbomachine part, comprising steps consisting of melting a titanium-aluminium intermetallic compound by plasma torch in a ring mould, extracting therefrom an ingot, as cast, in a state cooled from molten, cutting the ingot into at least one blank with an external shape that is simpler than the more complex one of said part to be manufactured, and machining the blank in order to obtain the part with said more complex external shape.

Method for manufacturing turbomachine components, blank and final component

The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase HOlevel in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce HOin comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.

Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2O2 level in cancer cells of a subject

The invention relates to a method for the treatment of an alloy based on titanium aluminide. The method comprises the following steps, during which no hot isostatic pressing is carried out: obtaining a semi-finished product () produced by centrifugal casting, then heat treating the semi-finished product in order to obtain an alloy microstructure comprising gamma grains and/or lamella grains (alpha2/gamma).

Heat treatment of an alloy based on titanium aluminide

The invention concerns a unit comprising a mold () adapted to receive a molten metal alloy and the said metal alloy poured therein. The alloy is TiAl. The mold is rotational and comprises receiving recesses () made of steel, metal alloy and/or ceramic, and, at the location of a plurality of section planes each passing through the mold and the poured metal alloy, the mold has a surface heat capacity less than that of the poured metal alloy.

Growing community of inventors

Moissy-Cramayel, France

Guillaume Martin