Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Guillaume Levilain

Pierre Wasnaire

Markus Follmann

Adrian Tersteegen

Alexandros Vakalopoulos

Peter Kolkhof

Klemens Lustig

Carsten Schmeck

Hanna Tinel

Christoph Gerdes

Stefan Heitmeier

Anja Buchmüller

Axel Kretschmer

Elisabeth Pook

Heiko Schirmer

Hartmut Beck

Chantal Fuerstner

Ursula Krenz

Thomas Neubauer

Matthias Beat Wittwer

Thomas Mondritzki

Lutz Lehmann

Kersten Matthias Gericke

Marie-Pierre Collin-Kroepelin

Norbert Witowski

Hana Cernecka

Karoline Droebner

Anja Buchmueller

Robert Fricke

Andreas Peter Broehl

Kartrin Partikel

Elisabeth Kersten

Stefanie Zimmermann

Nils Pfaff

Stefanie Mesch

Julia Dietze-Torres

Frank Süßmeier

Katrin Partikel

The invention relates to substituted S-alaninate derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.

Substituted S-alaninate derivatives

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Prodrugs of substituted triazole derivatives and uses thereof

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Wuppertal, Germany

Guillaume Levilain