Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Guillaume Levilain

Pierre Wasnaire

Adrian Tersteegen

Markus Follmann

Alexandros Vakalopoulos

Peter Kolkhof

Klemens Lustig

Carsten Schmeck

Alexander Hillisch

Lars Bärfacker

Hanna Tinel

Christoph Gerdes

Anja Buchmüller

Stefan Heitmeier

Axel Kretschmer

Elisabeth Pook

Heiko Schirmer

Hartmut Beck

Chantal Fuerstner

Ursula Krenz

Thomas Neubauer

Matthias Beat Wittwer

Thomas Mondritzki

Kersten Matthias Gericke

Lutz Lehmann

Frank Süssmeier

Marie-Pierre Collin-Kroepelin

Hana Cernecka

Norbert Witowski

Karoline Droebner

Anja Buchmueller

Andreas Peter Broehl

Robert Fricke

Kartrin Partikel

Elisabeth Kersten

Stefanie Zimmermann

Nils Pfaff

Stefanie Mesch

Julia Dietze-Torres

Frank Süßmeier

Katrin Partikel

The invention relates to substituted S-alaninate derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.

Substituted S-alaninate derivatives

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Prodrugs of substituted triazole derivatives and uses thereof

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Wuppertal, Germany

Guillaume Levilain