Centre National De La Recherche Scientifique

The Foundation for the Promotion of Industrial Science

Guillaume Gines

Teruo Fujii

Yannick Rondelez

Kevin Montagne

An object is to provide a component for molecular Computing and a method of molecular Computing. A component for molecular Computing, the component comprising: a microsphere including pores, at least some of which are open on a surface of the microsphere, and a plurality of modules grafted on the microsphere wherein each of the modules is a continuous s&#xe9;quence of nucleic acid base. A method of molecular Computing with a component comprising a microsphere including pores, at least some of which are open on a surface of the microsphere, and a plurality of modules grafted on the microsphere wherein each of the modules is a DNA strand, the method comprising steps of: designing the modules to create a molecular program! attaching the modules to the microsphere! bringing the microsphere into contact with a solution containing a mixture of enzymes! and incubating the microsphere with the modules at a constant temp&#xe9;rature so that DNA production and exchange happen locally between the grafted modules according to the molecular program.

Molecular computing component and method of molecular computing

An object is to provide a method of eliminating background amplification in detection of rare nucleic acids based on isothermal amplification. The method comprising steps of: preparing a mixture including solution and enzymes, and adding a first and a second template into the mixture, wherein the first template is an amplification template, and the second template is a leak absorption template. Methods to use this approach for multiplexed, ultrasensitive and ultra-specific detection of nucleic acids are presented.

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Tokyo, Japan

Guillaume Gines