Dana-Farber-Cancer Institute Inc.

Guillaume Adelmant

Bruce M Spiegelman

Pere Puigserver

Zhidan Wu

Jarrod A Marto

Scott B Ficarro

The present application relates to mass spectrometry methods for use in identifying proteins or other biomolecules which are bound irreversibly by test compounds.

Reagents and methods for analysis of proteins and metabolites targeted by covalent probes

The invention provides isolated nucleic acid molecules, designated PGC-1and PGC-1nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

PGC-1 isoforms and uses therefor

The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

PCG-1, a novel brown fat PPAR&#x3b3; coactivator

PGC-1, a novel brown fat PPAR&#x3b3; coactivator

PGC-1, a novel brown fat PPARgamma coactivator

PGC-1, a novel brown fat ppar&ggr; coactivator

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Boston, MA, United States of America

Guillaume Adelmant