Adjuvant Pharmaceuticals, LLC

Technology Resource International Corporation

Novartis Ag

Guigui Wang

William M Hung

Kai C Su

Katrina L Bergbauer

Sherry Wages

Dawn Smith

Jürgen Vogt

The present invention is directed to a water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives and methods of preparing water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent. The present invention is further directed to a pharmaceutical preserving composition comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.

Water soluble, randomly substituted partial N-, partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof

Water-soluble chitosan having a low concentration of endotoxin is disclosed. Products containing the water-soluble chitosan are also disclosed. Methods of making and using water-soluble chitosan having a low concentration of endotoxin are further disclosed.

Water-soluble chitosan having low endotoxin concentration and methods for making and using the same

Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof

A polymerizable composition comprising an effective amount of at least one tetrafunctional acrylate monomer. In one embodiment of the invention, a polymerizable composition is a compound comprising of at least 50 percent by weight of at least one tetrafunctional acrylate monomer, from 5 to 20 percent by weight of at least one modified bisphenol A epoxy diacrylate monomer, from 0 to 25 percent by weight of at least one acrylate monomer selected from aliphatic difunctional and polyfunctional acrylates, from 0 to 3 percent by weight of at least one UV absorber, and a source of free radicals. The lens-forming material resulted from the polymerizable composition is introduced to a lens mold with a mold cavity having a configuration conforming to the optical lens to be molded. A radiation energy source is used to cure the lens-forming material in the filled mold. The radiation energy source comprises a U-shaped UV light. The U-shaped UV light has a first arm capable of delivering UV light in a first direction and a second arm capable of delivering UV light in an opposite second direction. The first and second arms are spaced apart and substantially parallel to each other, thereby defining a space therebetween. The filled mold is placed at the center of the space therebetween the first and second arms to receive the radiations from the first and second directions for curing. The resultant lens has an inherently integrated &ldquo;hard-soft-hard&rdquo; structure cross-sectionally.

Polymerizable composition and optical articles using the same

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Cumming, GA, United States of America

Guigui Wang