Edmond Pharma, S.r.l.

Sigma Pharma Ltda.

Resfar S.r.l.

Resfar S.r.i.

Nature's Plus Farmacêutica Ltda.

Guido Vandoni

Giancarlo B Fregnan

Adriano Coelho

Heny Zaniboni

Marino Gobetti

Carlo Oliani

Giangiacomo Torri

Massimo Nicola

Marco Inglesi

The present invention describes the use of pharmaceutical compounds in pharmaceutical compositions for sublingual administration, including as active ingredient thereof, an agonist of the central receptor of benzodiazepinics chosen among diazepam, lorazepam, bromazepam, triazolam, alprazolam, flunitrazepam, nitrazepam and midazolam maleate, in a mixture with a pharmaceutical excipient consisting of, at least, 70% of the weight of the final formulation containing 40-45% by weight of lactose, 15-27% by weight of sorbitol and 12-16% by weight of cellulose.

Pharmaceutical composition based on agonist of benzodiazepine

The present invention refers to pharmaceutical compositions based on ketorolac or one of its salts pharmaceutically acceptable, as well as the use of ketorolac or one of its salts acceptable from pharmaceutical viewpoint, for preparation of a pharmaceutical composition (tablets) for sublingual administration, with the purpose of accelerating the pharmacological response to ketorolac, without making use of the injectable via. On the other hand, a pharmaceutical composition is described encompassing, as one of its active principles, ketorolac or one of its salts acceptable from pharmaceutical viewpoint, representing from 10 to 15% by weight, in relation to the total weight of the compound and as the essential excipient, a ternary mixture of lactose/sorbitol/cellulose, eventually in a mixture with other excipients acceptable from pharmaceutical viewpoint.

Sublingual Formulations of Ketorolac or Salts Thereof

Salts of a glutathione alkylester and anaminoacids

Inclusion complexes of dipyridamole with beta cyclodextrins in the molar ratio of dipyridamole to cyclodextrin ranging from 1:1 to 1:12 provides higher and more consistent blood concentrations than can be achieved by the dipyridamole alone.

Inclusion complexes of dipyridamole with cyclodextrins

Acetylsalicylic acid thioesters having antipyretic activity and useful for the symptomatic treatment of influenza of formula: ##STR1## wherein n is zero or 1, R.sub.1 is hydrogen, methyl or carboxy and R.sub.2 is hydrogen or an acetamido group; a process for their preparation by reacting a functional derivative of acetylsalicylic acid with the suitable thiol; and pharmaceutical compositions containing them as active ingredient.

Acetylsalicylic acid thioesters, a process for their preparation and

The compound having formula (I) ##STR1## is obtained by reacting 1,2-diphenyl-4-[2-phenylsulfinyl)-ethyl]-4-hydroxymethyl-pyrazolidine-3,5- dione (hydroxymethylsulfinpyrazone) with nicotinic acid, in the presence of activating agents such as DCCD. (I) is endowed with marked vasodilating, antiaggregating and hypocholesterolemic properties.

Compound having vasodilating, antiaggregating and hypocholesterolemic

The present invention concerns novel phthalidyl esters of arylalkanoic acids having improved pharmacological properties in respect to the corresponding arylalkanoic acids having analgesic and anti-inflammatory activity, as well as pharmaceutical compositions containing them as active ingredients. The invention further relates to a method for improving the pharmacological properties of said arylalkanoic acids having analgesic and anti-inflammatory activity, by introducing, through an ester bond, a phthalidyl group.

Analgesic and anti-inflammatory arylalkanoic acid phthalidyl esters and

This invention relates to a derivative of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl indole-3-acetic acid with 3-oxo-1-isobenzofuranyl, linked by an ester bond, more particularly to 1-(p-chlorobenzoyl)-5-methoxy-2-methyl indole-3-acet-3-oxo-1-isobenzofuranyl ester, as well as to its preparation and therapeutical use as an analgesic and anti-inflammatory agent. Said compound is prepared by reacting equi-molecular amounts of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl indole-3-acetic acid and bromophthalide a few hours at room temperature, under a mild stirring, in the presence of a base.

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Correzzana, Italy

Guido Vandoni