Hoechst Aktiengesellschaft

Dade Behring Marburg Gmbh

Guido Simons

Hans Wissmann

Peter Molz

Gerd Schnorr

Helmut Strecker, Deceased

Heinz Jurgen Skrzipczyk

Henning Hachmann

Stephan Neuenhofer

Helmut Strecker

Heinz-Jurgen Skrzipczyk

Kurt E Weimer

A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active compound being in mutual equilibrium, by

Process and test kit for determining free active compounds in biological

The invention relates to a process for the stabilization of biologically active substances which are immobilized on a carrier, where the solid phase with the immobilized biologically active substance is contacted for the stabilization with a solution which contains polyanetholesulfonic acid and/or salts thereof. The biologically active substances are, in particular, antibodies.

Process for the stabilization of biologically active substances

The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R.sup.1 and R.sup.2 are identical or different and denote hydrogen or iodine, and R.sup.3 denotes H or alkyl, a process for the preparation of the compounds, and their use when carrying out immunoassays.

Novel thyronine derivatives

The invention relates to new thyronine derivatives of the formula ##STR1## in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R.sup.1 and R.sup.2 are identical or different and denote iodine or hydrogen, and R.sup.3 denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.

Thyronine derivatives

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Ingelheim am Rhein, Germany

Guido Simons