International Society for Drug Development S.r.l.

Purytra Farmaceutici S.r.l.

Guido Puricelli

Simona Rapposelli

Claudia Martini

Amedeo Columbano

Sheraz Gul

Andrea Perra

Simona Sestito

Massimiliano Runfola

Vincenzo Calderone

Simona Daniele

Grazia Chiellini

The invention concerns a compound of Formula (I) or a salt thereof, wherein Ris H, (C-C)alkyl or CF; Ris H, (C-C)alkyl or CF; A is CHCOOH, XCHCOOCHCH, XCHCOOH, XCHCHNH, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where Ris H, —CH, —CHCHor CHCO—, Ris H or —CH, R5 is H or —CH, and Ris H or —CH. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TRβ).

Thyromimetics with a biphenylmethane scaffold and their use

The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumors such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.

2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1

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Milan, Italy

Guido Puricelli