B.r.a.i.n. Biotechnology Research and Information Network Ag

Basf Se Corporation

Evonik Operations Gmbh

Roquette Freres

Brain Ag

Cyplus Gmbh

Cvplus Gmbh

Pure Circle Sdn Bhd

Brain Biotech Ag

Erbslöh Geisenheim Gmbh

Guido Meurer

Avetik Markosyan

Esther Gabor

Jürgen Eck

Yvonne Tiffert

Andreas Buthe

Andrea Christiansen

Xin Lu

Franz Kaufmann

Martin Langer

Stephen Gos

Benedikt Hoffmann

Andreas Hafner

Claudia Borgmeier

Gordon Bradley

Daniel Johannes Koch

Stefan Pelzer

Stella Molck

Daniel Petri

Rose Whelan

Sophie Huchette

Sébastien Maubourguet

Ester Gabor

Hans-Jörg Koch

Jörg Mampel

Anke Bachert

Jessica Kleinbölting

Jürgen Fröhlich

Maike Kipker

Kiran Doranalli

Sandra Herbold

Babette Fiedler

Jörg Reichert

Jörg BÜSCHER

Bendikt Hoffmann

Jorg Reichert

Marco Fiedler

Petra Zurek

Joerg Buescher

Christian Naumer

A genetically modifiedstrain has been transformed with an optimized vector, mainly for producing a D-psicose 3-epimerase.

Genetically modifiedstrain, optimized vectors, and uses thereof

The invention provides an assay for identifying a bacterium capable of binding elemental heavy metal, comprising the following steps: cultivating a test bacterium in a suitable first culture medium; immersing at least a surface portion of a test tool into the first culture medium for a second predetermined period of time, said surface portion being coated by elemental heavy metal, respectively; removing said test tool from said first culture medium and optionally rinsing the test tool; contacting a second culture medium with the surface portion coated by elemental heavy metal of said test tool removed in the previous step; and identifying the test bacterium as being capable of binding elemental heavy metal from growth of the test bacterium in said second culture medium.

Biological ore processing for the isolation of heavy metals

Suggested is a method for recovering precious metals from secondary resources comprising or consisting of the following steps: (a) providing a source of solid waste material comprising precious metals in an amount of at least 0.0001% b.w.; (b) bringing said waste material into contact with heterotrophic micro-organisms capable of producing and releasing hydrocyanic acid; (c) adding a solvent or an aqueous nutrient solution capable of serving as a nutrient source for said micro-organisms to the mixture; (d) depleting said waste materials from the precious metals contained therein by complexation of the metals with said hydrocyanic acid released by said micro-organisms; (e) separating the depleted solid waste material from the liquid containing the metal-cyano complexes; (f) recovering the precious metals from their cyano-complexes in known manner.

Process for recovering precious metals from secondary resources

The current invention concerns a newstrain with strong inhibition ofand its use as a probiotic.

strain with probiotic activity

The invention provides a process of isolating or enriching a heavy metal present in a liquid medium. The process comprising the following steps: (a) incubating a suspension containing (i) particulate scrap metal, household waste and/or industrial waste containing a heavy metal in elemental form and (ii) biomass comprising a bacterium, or a combination of two or more bacteria, capable of binding the heavy metal; (b) separating the biomass having bound heavy metal from the suspension of step (a); and (c) isolating the heavy metal from the biomass separated in step (b).

Biological processing of scrap metal, household waste and/or industrial waste for the isolation of heavy metals

The invention provides a process of isolating or enriching a heavy metal present in a suspension containing a particulate mineral ore containing a heavy metal, comprising the following steps: incubating a suspension containing (i) a particulate mineral ore containing a heavy metal and (ii) biomass comprising a bacterium capable of binding the heavy metal; separating the biomass having bound heavy metal from the suspension of the previous step; and isolating the heavy metal from the biomass separated in the previous step.

The present invention relates to a host cell having an elevated expression or activity of an enzyme as compared with the parent cell from which it has been derived, said enzyme having lactoyl-CoA reductase activity. Furthermore, provided is a method of producing lactaldehyde and/or 1,2-propanediol, said method comprising culturing said host cell and/or utilizing said enzyme to produce said compound.

Means and methods for producing propanediol

The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invention furthermore relates to a method of coating and/or impregnating a material, comprising contacting the material with the chimeric protein or the composition of the invention.

Chimeric surface active proteins

The present invention provides the use of surface active proteins, especially class I and class II hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.

Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin

By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.

Method of treating cellulosic materials with hydrophobins

The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.

Surface active proteins as excipients in solid pharmaceutical formulations

Growing community of inventors

Seeheim-Jugenheim, Germany

Guido Meurer