Novartis Ag

Ciba-geigy Corporation

Other

Ciba Specialty Chemicals Corporation

Mitsubishi Pharma Corporation

Taito Company, Ltd.

Novartis Pharma Gmbh

Guido Jordine

Jean-Marie Adam

Michael Mutz

Tadashi Mishina

Tetsuro Fujita

Stephan Abel

Ryoji Hirose

Volker Brinkmann

Markus Zollinger

Claudia Sayer

Stefan Abel

The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.

Organic compounds

This invention relates to certain ceramide-analogues of FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol; fingolimod). In particular, the present invention relates to pharmaceutical compositions comprising these compounds, as well as processes for their preparation and their use in the treatment of autoimmune conditions, such as multiple sclerosis.

Ceramide-analogous metabolites

The present invention relates to crystalline forms and hydrates of 2-Amino-2-[2-(4-C-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.

Polymorphic crystal forms of 3-methylthiophene-2-carboxylic acid (6S,9R,10S,11S,13S,16R, 17R)-9-chloro-6-fluoro-11-hydroxy-17-methoxycarbonyl-10,13,16-trimethyl-3-oxo-6,7,8,9,10, 11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester. The crystal forms possess anti-inflammatory activity and have very good stability. Methods for preparing the crystal forms are also described.

Polymorphis of a known thiophenecarboxylic acid dodecahydrocyclopenta (a) phenanthrenyl ester

Disclosed is a process for the production of 2-amino-2-[2-(4-C-alkyl-phenyl)ethyl]propane-1,3-diols.

Production of 2-amino-2-[2- (4-alkylphenyl) ethyl] propane-1, 3-diols

Disclosed is a process for the production of 2-amino-2-&lsqb;2-(4-C -alkyl-phenyl)ethyl&rsqb;propane-1,3-diols.

Production of 2-amin-2-&lsqb;2-(2-(40-C2-20-alkyl-phenyl)ethyl&rsqb;propane-1,3-diols

Dye mixtures comprising at least one dye of formula ##STR1## together with at least one dye of formula ##STR2## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 -alkanoylamino, halogen or sulfo, R.sub.3 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkanoylamino, halogen or sulfo, and Y is C.sub.1 -C.sub.4 alkyl or phenyl or naphthyl, each of which is unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkanoylamino, halogen or sulfo, which dye mixtures contain at least 10% by weight of one or more than one dye of formula (1), based on the total amount of the dyes of formulae (1) and (2), dye nitrogen-containing or hydroxyl group-containing fiber materials with good properties.

Azo dye mixtures and the use thereof

The invention relates to a process for the preparation of compounds of formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or sulfo, and R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl, which process comprises reacting a compound of formula ##STR2## wherein Hal is halogen and R.sub.1 has the meaning given above, with a compound of formula ##STR3## wherein Y is a saponifiable group and R.sub.2 has the meaning given above, to give the compound of formula ##STR4## wherein R.sub.1, R.sub.2 and Y have the meanings given above, and saponifying the compound of formula (4) to give the compound of formula (1). The compounds of formula (1) are suitable for the synthesis of dyes.

Process for the preparation of aminodiphenylamine compounds

A process for dyeing or printing polyamide material by the trichromatic technique using a dye mixture which contains least two yellow- or orange-dyeing dyes of formula (1) ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen, and X is hydrogen or C.sub.1 -C.sub.4 alkyl; together with at least one red-dyeing dye of formulae (2) and (3) ##STR2## wherein R.sub.2 is C.sub.1 -C.sub.6 alkyl, phenyl or cyclohexyl and R.sub.3 is C.sub.1 -C.sub.6 alkyl, or wherein R.sub.2 and R.sub.3, together with the linking nitrogen atom, form an azepinyl ring, and R.sub.4 is hydrogen, C.sub.2 -C.sub.4 alkanoylamino or halogen; and together with at least one of the blue-dyeing dyes of formulae (4) and (5) ##STR3## wherein R.sub.5 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.6 is C.sub.1 -C.sub.4 alkyl or amino, R.sub.7 is hydrogen or methyl, and R.sub.8 is a C.sub.2-4 hydroxyalkylsulfamoyl radical, is disclosed.

Process for trichromatic dyeing or printing

Reactive dyes of formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or C.sub.1 -C.sub.4 alkyl,

Fiber-reactive monoazo dyes containing a phenylamino-substituted

The fibre-reactive dyes of the formula ##STR1## where the variables are each as defined in the claims, are suitable in particular for dyeing nitrogen-containing and hydroxyl-containing fibre materials.

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Freiburg, Germany

Guido Jordine