Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Guido Grueter

Thomas Schlaubitz

Paul Federer

Christian George

Torsten Burdack

Andreas Scholle

Guenter Tenzler

Daniel Bommer

Stefan Job

The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in a microtiter plate format.

Thermocycling of a block comprising multiple sample

Disclosed herein are methods for monitoring a thermoelectric heating and cooling device () of a system () for cycling liquid reaction mixtures through a series of temperature excursions, and such systems adapted to perform these methods. A first quantity being either an electric current or an electric voltage is applied to the heating and cooling device () or a portion () thereof (), and a second quantity being either the non-selected first quantity or temperature is measured to obtain a first test value. The selected first quantity is applied to another thermoelectric heating and cooling device () or another portion () of the first device (), and the second quantity is measured to obtain a second test value. Comparison of the first and second test values yields a monitoring value which is compared with a pre-defined threshold value to obtain a monitoring result.

System and methods for monitoring a thermoelectric heating and cooling device

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Gisikon, Switzerland

Guido Grueter