Bayer Aktiengesellschaft

Other

Lanxess Deutschland Gmbh

Saltigo Gmbh

Guido Giffels

Thomas Prinz

Claus Dreisbach

Joachim Kralik

Inga Ritzkopf

Christian Steffens

Walter Lange

Karlheinz Drauz

Guido Steffan

Christian Wandrey

Paul Naab

Andreas Bommarius

Udo Kragl

Herbert Diehl

Jürgen Kintrup

Michael Kreis

Birgit Driessen-H&ouml;lscher

Georg Martin

Erich Hammerschmidt

Florian Rampf

Torsten Pohl

Wolfram Sirges

Matthias Gotta

Lutz Frohn

Carsten Bolm

Andreas Schulze Tilling

Björn Schlummer

Antje Hieronymi

Florian Andreas Rampf

Oliver Krebs

Nadine Derrien

Hans-Jürgen Grob

Marcel Felder

Birgit Drieben-Hölscher

Jörg-Dietrich Jentsch

Gerald John

Hans-Jürgen Gross

Process for the preparation of polyfunctional amines of the formulae  

Process for the preparation of aminoalkylamines

The present invention relates to a process for preparing optionally substituted arylsulphonic anhydrides of the general formula (I) 

Process for preparing optionally substituted arylsulphonic anhydrides

Alcohols prepared by reacting carboxylic acids and/or carboxylic esters with hydrogen in the presence of a special catalyst.

Process and catalyst for preparing alcohols

The invention relates to the biphenyldiols of the formula (V) The corresponding racemic and enantiomerically pure triflate compounds thereof, where Rand Rare H, Ris chlorine, and Ris methoxy. In an alternate embodiment, Rand Rare hydrogen and Rand Rare C-C-alkoxy, fluorine, or chlorine.

Biphenydiols

Diphosphines

The invention relates to the preparation of enantiomerically pure bis-diphenylphosphine oxides in a particularly advantageous manner by (1) reacting an aromatic bromine compound with a diphenylphosphinic chloride in a mixture of tetrahydrofuran and an aromatic hydrocarbon to give a diphenylphosphine oxide, which is isolated from a solution in an aromatic hydrocarbon by adding a saturated aliphatic hydrocarbon; (2) metalating the resulting diphenylphosphine oxide in the 6-position and reacting the metalated diphenylphosphine oxide with iodine at temperatures not less than &minus;25&deg; C. in such a way that a small amount of iodine is always present in excess, giving a 2-iodo-diphenylphosphine oxide; (3) preparing a racemic bis-diphenylphosphine oxide from the resulting 2-iodo-diphenylphosphine oxide using copper and an aromatic hydrocarbon solvent and crystallizing the racemic bis-diphenylphosphine oxide from a solution in an aromatic hydrocarbon; and (4) separating isomers using an enantiomerically pure mono- or dicarboxylic acid to obtain a first enantiomer by crystallization from a solution in an aromatic hydrocarbon and obtaining a second enantiomer by hydrolysis and subsequent crystallization from a solution in an aromatic hydrocarbon.

Process for the preparation of enantiomerically pure (5, 5&prime;-dichloro-6,6&prime;-dimethoxy-biphenyl-2,2&prime;-diyl)- bis(diphenylphosphine oxides)

Piperidines are prepared in an advantageous manner by catalytic hydrogenation of activated pyridines in the presence of palladium catalysts if the palladium catalyst is palladium-on-carbon and the solvents are aromatic hydrocarbons.

Process for preparing piperidines

Grignard reagents which contain a protected aldehyde function are obtained in a particularly advantageous manner from a halogenated aldehyde by reaction with a secondary monoamine to give an open-chain aminal, and conversion of the latter into a Grignard reagent using metallic magnesium. The invention also relates to novel Grignard reagents of this type.

Process for the preparation of Grignard reagents and novel Grignard reagents

2-Methoxyethoxy-benzenes are obtained in an advantageous manner from the corresponding phenol compounds by reaction with 2-chloroethyl methyl ether if the process is carried out without the addition of a strong solvent at temperatures above 95&deg; C. and under pressure. The present invention also relates to novel 2-methoxyethoxybenzyl cyanides.

Process for the preparation of 2-methoxyethoxy-benzenes and novel 2-methoxyethoxy-benzyl cyanides

The invention involves a procedure for the catalytic enantioselective reduction of ketones to chiral alcohols. Heretofore, this reaction was carried out batch-wise. Because, in this procedure, one utilizes a catalyst increased in size with polymer, it is possible to carry out the reaction in a quasi-continuous manner in a membrane reactor. In contrast to the state of the art, one thus dramatically increases the operative life of the catalyst.

Process for the catalytic enantioselective reduction of ketones

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Bonn, Germany

Guido Giffels