The United States of America As Represented by the Secretary of

The United States of America As Represented by the Secretary, Department

Guido Francois

Michael R Boyd

Gerhard Bringmann

John H Cardellina, Ii

Kirk P Manfredi

Christoph Schneider

J David Phillipson

Georges Timperman

Laurent Ake Assi

Yaii F Hallock

The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining such derivatives, and methods of using such antimalarial compounds for the prevention of malaria infections in mammals and for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.

Antimalarial naphthylisoquinoline alkaloids and pharmaceutical

The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.

Antimalarial korupensamines and pharmaceutical compositions and medical

Growing community of inventors

Oostende, Belgium

Guido Francois