American Cyanamid Company

Shell Research Limited

Basf Aktiengesellschaft

Shell Internationale Research Maatschappij, B.v.

Wyeth

Celamerck Gmbh & Co. Kg

Shell Agrar Gmbh & Co., Kg

Guido Albert

Jurgen Curtze

Annerose Edith Rehnig

Klaus-Juergen Pees

Waldemar F Pfrengle

Henry Van Tuyl Cotter

Ludwig Schroder

Edmund Friedrichs

Leslie May

Guenter Krummel

Christine Helene Rudolph

Ewald Gerhard Sieverding

Juergen Curtze

Henry Van Cotter

Werner E Simon

Heinz-Manfred Becher

Christo A Drandarevski

Gunther Reichert

Gerd Morschhaeuser

Karl-Otto Stumm

Paul Carter

Andreas Waldeck

Eberhard Ammermann

Helmut Pieper

Jordi Tormo I Blasco

Josef Nickl

Donald R Kirsch

Sigmund Lust

Klaus-Jurgen Pees

Mark R Schmitt

Klaus-Jüergen Pees

Dietrich Eichler

Paul A Carter

Klaus-Jürgen Pees

Jane E Harris

Debra Search

Arthur A Ramsey

Carl F Beyer

The novel compounds of formula I:wherein (R, R, Hal and Lthrough Lare defined in the specification) show selective fungicidal activity. The new compounds may be processed with carriers and adjuvants to produce fungicidal compositions.

Fungicidal trifluoromethylalkylamino-triazolopyrimidines

The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

Substituted-triazolopyrimidines as anticancer agents

5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines of formula I: (I) in which Ris hydrogen, fluoro, alkyl, alkenyl, alkynyl, alkadienyl, where the carbon chains of these radicals may be unsubstituted or substituted as defined in the description; Ris hydrogen, alkyl, alkenyl, alkynyl, alkadienyl, where these radicals may be unsubstituted or substituted; Ris fluoroalkyl or fluoroalkenyl; X is halogen; n is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy. Processes for their preparation, compositions containing them and to their use for combating phytopathogenic fungi. 

5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides

The novel compounds of formula I: wherein

Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines

Fungicidal trifluorophenyl-triazolopyrimidines

The novel optically active compounds of formula I:

The novel compounds of formula I: ##STR1## (R.sup.1, R.sup.2 and Hal are defined in the specification) show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.

Fungicidal 7-alkyl-triazolopyrimidines

An improved process for the preparation of (S)-1,1,1-trifluoroalkyl-2-amines of formula IIIA, ##STR1## where R.sup.1 is a C.sub.1-6 alkyl group, from the corresponding racemic mixture, which process includes treating 1 part by mole of the racemic mixture with approximately 0.3 to 0.7 part by mole of D-(-)-tartaric acid in the presence of an inert solvent.

The invention provides a fungicidal composition comprising at least one systemic, contact and/or soil fungicide and at least one acrylic acid morpholide derivative of the general formula ##STR1## in which R.sub.1 represents a hydrogen, chlorine or bromine atom, a trifluoromethyl, trifluoromethoxy, C.sub.3 -C.sub.7 alkyl, C.sub.3 -C.sub.5 alkoxy, C.sub.3 -C.sub.6 alkenyl, HClFC--CF.sub.2 O--, HClC.dbd.CClO--, cyclohexyl, cyclopentenyl, cyclohexenyl, phenyl, 4-chlorophenyl, 4-ethylphenyl, 4-chlorobenzyl or 4-chlorophenylthio group or a phenoxy group optionally substituted by one or more substituents selected from fluorine and chlorine atoms and methyl and ethoxycarbonyl groups and R.sub.2 represents a hydrogen atom, or R.sub.1 represents a hydrogen atom and R.sub.2 represents a 3-phenoxy group.

Fungicidal compositions

The novel compounds of formula I: ##STR1## wherein R.sup.1, R.sup.2, Hal and L.sup.1 through L.sup.5, are defined in the specification show selective fungicidal activity.

Substituted benzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.

Fungicidal 2-methoxybenzophenones

Substituted benzoic acid compounds are disclosed, having the formula: ##STR1## The compounds find use as intermediates for the production of agricultural fungicides.

5-bromo-2-methoxy-6-alkyl benzoic acids

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Hackenheim, Germany

Guido Albert