Schering Aktiengesellschaft

Guenter Neef

Walter Elger

Sybille Beier

Eckhard Ottow

Rudolf Wiechert

Krzysztof Chwalisz

David A Henderson

Stefan Scholz

Gerhard Sauer

Helmut Hofmeister

Ulrich Eder

Ralph Rohde

Henry Laurent

Ulrich Klar

Andreas Huth

Dieter Seidelmann

Ralph Schmiechen

Martin Haberey

Klaus Annen

Gregor Haffer

Karl-Heinrich Fritzemeier

Mogens Engelstoft

Arwed Cleve

Dieter Rahtz

Gerald Kirsch

Wolfgang Losert

Wolfgang Kehr

Andreas Steinmeyer

Ruth Thieroff-Ekerdt

Herbert Wiesinger

Claus T Braestrup

Dieter Palenschat

Marianne Fahnrich

Jogen A Christensen

Krzsysztof Chwalisz

Juergen Bardenhagen

Harry Vierhufe

Klaus Stoekemann

Katiea Schwarz

Compounds of Formula I, wherein Y, Y, R&#x2013;R, Q and Z are as defined herein, are vitamin D derivatives. These compounds are useful for, e.g., the treatment hyperprolifierative diseases of the skin, tumor diseases and precancerous stages, auto-immune diseases, rejection reactions in the case of autologous, allogenic or xenogenic transplants, AIDS, atopic skin conditions, secondary hyperparathyroidism, renal osteodystrophia, senile and postmenopausal osteoporosis, diabetes mellitus type II, degenerative diseases of the peripheral and central nervous system, hypercalcemias, granulomatous diseases, paraneoplastic hypercalcemias, hypercalcemias in hyperparathyroidism, hirsutism, ateriosclerosis, and/or inflammatory diseases.

Vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments

Steroid esters and amides, process for their production and their pharmaceutical use

There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH;

13-alkyl-11beta-phenylgonanes

13-alkyl-11.beta.-phenylgonanes

11.beta.-phenyl-4,9,15-estratrienes, their manufacture and

11.beta.-substituted steroids of the formula ##STR1## wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H;

11.beta.-alkynyl-estrenes and -estradienes, their production and

A combination product contains oxytocin and/or an oxytocin analog and an antigestagen for induction of birth.

Oxytocins and antigestagens in combination for induction of birth

13alpha-alkylgonan-delta.sup.9(11) -5,10 epoxides of the formula ##STR1## in which R is a hydrogen, methyl or ethyl and

13alpha-alkylgonan-delta 9(11)-5,10-epoxides

Descriptions are given of 11.beta.-aryl-estradienes of general formula I ##STR1## where X means an oxygen atom or a hydroxyimino group N.about.OH, where the hydroxy group may be in the syn or anti position,

11 Beta-N,N-dimethylaminophenyl-estradienes, their manufacture and

3-Substituted beta-carbolines of the formula ##STR1## wherein R.sup.A is H, F, Cl, Br, I, NO.sub.2, CN, CH.sub.3, CF.sub.3, SCH.sub.3, NR.sup.16 R.sup.17 or NHCOR.sup.16,

Pharmacologically active 3-substituted beta-carbolines useful as

Compounds of the formula I ##STR1## wherein R.sub.1 is ##STR2## wherein R.sup.I and R.sup.II each independently is alkyl of 1-4 carbon atoms, or R.sup.I and R.sup.II together with the connecting N-atom form a 5- or 6-membered heterocyclic ring whose remaining atoms are all C-atoms, or which also includes and additional N-atom, an additional O or S atom or a combination thereof; ##STR3## wherein R.sup.I and R.sup.II are as defined above; --SR.sup.III, wherein R.sup.III is methyl, ethyl or phenyl; or

11.beta.-aryl estradienes, processes for their production and

Novel 1,3-dialkoxy 8.alpha.-estratriene compounds of the formula ##STR1## WHEREIN R.sub.1 is alkyl of 1-18 carbon atoms, R.sub.2 is alkyl of 1-5 carbon atoms and Ac is alkanoyl of 1-8 carbon atoms, are obtained by a three-step synthesis from a tetrahydroindane-5-one compound.

Process for the preparation of 1,3-oxygenated 8.alpha.-estratrienes and

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Berlin, Germany

Guenter Neef