Kabivitrum Ab

Kabi Ab

Gudrun E Backstrom

John Y Thunberg

Ulf P Lindahl

Lars-Olov Andersson

Erik Yngve Holmer

Ewa G Soderstrom

Lars-Ake Fransson

Inga H Sandberg

The invention relates to an oligosaccharide which contains 4-8 monosaccharide units and which is characterized in that it contains at least one glucosamine unit which is 3-0-sulfated, and at least one additional glucosamine unit, whereby these units are linked via an intermediate monosaccharide unit, which is bound to the reducing end of the 3-0-sulfated glucosamine unit. The invention further relates to a pharmaceutical composition containing one or more such oligosaccharides, and to a process for the preparation of these oligosaccharides.

Oligosaccharides having selective anticoagulation activity

Heparin fragments having selective anticoagulation activity having 14-18 sugar units, the disaccharide unit L-iduronosyl-2-O-sulphate-N-sulpho-U-glucosamine-6-O-sulphate being the main component, and where unsulphated L-iduronic acid is in a position situated 3-5 sugar units from the unreducing terminal. Pharmaceutical compositions containing such heparin fragments. Processes for the preparation of the heparin fragments.

Heparin fragments having selective anticoagulation activity

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Alunda, Sweden

Gudrun E Backstrom