Los Angeles Biomedical Research Institute at Harbor-ucla Medical Center

Guanpingsheng Luo

Ashraf S Ibrahim

John E Edwards, Jr

Yue Fu

Brad J Spellberg

Michael R Yeaman

Lin Lin

The disclosure features isolated polypeptides of Hyr1. The disclosure further features vaccines and antibodies useful in treating or preventing candidiasis orinfections or both. Further disclosed are isolated polypeptides consisting of between 14 and 20 amino acids for vaccine preparation. The specific amino acid sequences of isolated polypeptides of Hyr1 are also disclosed.

HYR1-derived compositions and methods of treatment using same

The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization againstinfection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization againstinfection. The compositions and methods of the invention are useful for preventing or treatinginfections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR)infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR)infections.

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The invention features HYR1 as a vaccine target and as a prophylactic strategy for combating disseminated candidiasis.

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Torrance, CA, United States of America

Guanpingsheng Luo