Alios Biopharma, Inc.

Janssen Biopharma, Inc.

Icn Pharmaceuticals, Inc.

Janssen Biotech, Inc.

Other

Janssen Pharmaceutica Nv

Biota Scientific Management Pty Ltd

Ribapharm Inc.

Janssen Pharmaceuticals, Inc.

Valeant Pharmaceuticals International

Biota, Inc.

Valeant Research and Development

Guangyi Wang

Leonid Beigelman

David Bernard Smith

Jerome Deval

Marija Prhavc

Natalia Dyatkina

Robert C Tam

Vivek Kumar Rajwanshi

Minghong Zhong

James Patrick Edwards

Peter J Connolly

Stuart Emanuel

Devron R Averett

Gilles C Bignan

Anh P Truong

Santhosh Kumar Thatikonda

Mark Richter

Phillip Dan Cook

Haiying He

Yi Jin

Thomas W Bruice

Daniele Andreotti

Johnson Lau

Janet M Leeds

Jennifer L Brooks

Vivek K Rajwanshi

Carmela Napolitano

Nicholas A Boyle

Maria Eugenia Ariza

Patrick C Fagan

Kathleen D Tucker

Christian Andreas Jekle

Zhi Hong

Kandasamy Ramasamy

Kanda S Ramasamy

Karin Ann Stein

Marcel Viellevoye

Anh Truong

Tianbao Lu

Jean-Luc Girardet

Zbigniew Pietrzkowski

Esmir Gunic

Sylvie Laquerre

Johannes Wilhelmus John Fitzgerald Thuring

Wilfried E Seifert

Michael Hunter Welch

Wim Schepens

Wim Bert Griet Schepens

Johannes Wilhelmus J F Thuring

Sylvia Laquerre

Wim Gert Griet Schepens

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

Substituted nucleosides, nucleotides and analogs thereof

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R, R', X, B, R, R&#x2032;, B, X, R, Z-M-Y, and Y-M-Zare as defined herein. 

Cyclic dinucleotides as sting agonists

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R, R, R, R, B, W, X, Y, Z are defined herein.

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV and/or HIV infection with one or more nucleotide analogs.

Acyclic antivirals

Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R, R, B, R, and Rare defined herein.

Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

Antiviral compounds

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:  wherein R, R, R, and Rare defined herein.

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

Compounds for the treatment of paramyxovirus viral infections

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV and/or HIV infection with one or more nucleotide analogs.      

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.

Growing community of inventors

Carlsbad, CA, United States of America

Guangyi Wang