Invisishield Technologies Ltd.

Eureka Therapeutics, Inc.

Guangyan Xiong

Cheng Liu

Zhiyuan Yang

Hongbing Zhang

Ziyou Cui

Jinyun Chen

Warner Greene

Hong Liu

Yiyang Xu

Pengbo Zhang

Lianxing Liu

Javier Morales

Hongruo Yun

Shan Li

Motao Liu

Lu Jin

Jingbao Liu

Jun Cui

Xiaomei Ge

Yixiang Xu

Shaohua Xu

The present application provides chimeric proteins comprising an antibody moiety that specifically binds to a component of an influenza virus or a variant thereof, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating an infection caused by an influenza virus or a variant thereof in an individual.

Chimeric protein comprising an anti-influenza virus antibody moiety and a mucoadhesive peptide fragment for preventing or treating influenza infections

The present application relates to compositions for preventing or treating infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety comprising an extracellular binding domain (EBD) of an angiotensin-converting enzyme 2 (ACE2) protein or a fragment thereof that specifically binds to an S protein, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating a viral infection in an individual, such as a coronavirus infection.

Compositions for preventing or treating coronavirus infections

Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.

Constructs trageting CD22 and uses thereof

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Emeryville, CA, United States of America

Guangyan Xiong