Corning Incorporated

Guangshan Li

Mingqian He

Yuming Xie

Xinying Xie

Yijia Bao

Nalini Raghavachari

Anping Liu

Norman Henry Fontaine

Jinlin Peng

James Gregory Couillard

Joydeep Lahiri

Donnell Thaddeus Walton

A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Variable penetration depth biosensor

Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors

A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

Treatment of substrates for immobilizing biomolecules

Growing community of inventors

Corning, NY, United States of America

Guangshan Li