University of Kentucky Research Foundation

Bioventures, LLC

Other

The United States Government As Represented by the Department of Veterans Affairs

University of Arkansas

Guangrong Zheng

Peter Anthony Crooks

Linda P Dwoskin

Sangeetha Sumithran

Daohong Zhou

Jianhui Chang

Yingying Wang

Xuan Zhang

Roger Lee Papke

Zhenfa Zhang

Wei Feng

Yi Luo

Lijian Shao

Paul Lockman

Dennis Keith Miller

Zhenfa Zheng

Xingui Liu

Stefan Kwiatkowski

Jon Scott Thorson

Cesar M Compadre

David S Watt

Philip J Breen

Jared T Hammill

Martin Hauer-Jensen

Vladimir P Grinevich

Marlon D Jones

Marharyta Pivavarchyk

Justin R Nickell

Kip Guy

Peiyi Zhang

Yonghan He

Sajid Khan

Derong Ding

Na-Ra Lee

Mark Leggas

Zheng Cao

Seth Davin Norrholm

David Allen

Sairam Krishamurthy

Seth Davin Norholm

Davis D Allen

The present disclosure provides compositions and methods for selectively killing cancer cells, wherein the composition comprises a compound of Formula (I). The selective killing of cancer cells occurs with an improved potency and safety profile compared to similar compounds. In particular, the compositions and methods of the invention show reduced platelet toxicity and retained or improved toxicity in cancer cells.

BCL-2 proteins degraders for cancer treatment

The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.

Piperlongumine analogues and uses thereof

The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse

The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises a compound of Formula (I) or a compound of Formula (II). The selective killing of senescent cells may delay aging and/or treat age-related disorders.

Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof

The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine (PL) or derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.

Compositions and methods for selectively depleting senescent cells

Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors

Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.

Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors

Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors

Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogs are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.

Methods for making tocoflexols and analogues thereof

Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and/or gastrointestinal tract disorders.

[object Object]

Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and or gastrointestinal tract disorders.

Growing community of inventors

Lexington, KY, United States of America

Guangrong Zheng