Alfred E. Mann Foundation for Scientific Research

Axonics Modulation Technologies, Inc.

Axonics, Inc.

Guangqiang Jiang

Dennis Lynn Schroeder

John Woock

Eric V Schmid

Gary D Schnittgrund

Charles L Byers

Attila Antalfy

Joseph H Schulman

Kate E Purnell

John Charles Gord

Raymond W Cohen

Tom He

Prabodh Mathur

Brian R Dearden

Ross Davis

Siegmar Schmidt

Howard H Stover

Daniel Rodriguez

Dennis Schroeder

Atilla Antalfy

Henry J Lee

Rinda Sama

Faizal Abdeen

Andres Dandler

Ronaldo Fernandez Carreon

Kate E Fey

William T Mcclellan

Charles Borlase

Justin R Chambers

Zachary Hoopes

Jaschar Shakuri-rad

Eric Schmid

John Gord

Brian Dearden

Methods and devices for facilitating remote programming of an implanted neurostimulation device are provided herein. Such methods include establishing communication between an implanted pulse generator of the neurostimulation system and a remote device associated with a remote support entity through one or more intermediary devices. The intermediary devices can include any of: a patient remote, a charger, a specialized communicator device, a plug-in accessory, and a patient device to facilitate communication of patient and program information for a current neurostimulation therapy. The remote device determines or receives a program update of one or more parameters or a new neurostimulation program and updates the implantable pulse generator through the intermediary devices. The patient device and remote device can further include a software framework to facilitate communication between the patient and the remote support entity in a live programming session, as well as collecting subjective/objective patient information regarding the current treatment.

Devices and methods for remote programming of implanted neurostimulation systems

Embodiments include implantable neurostimulation leads configured to reduce current leakage following implantation in a patient's body, and methods of manufacturing such leads. A lead includes a lead body with proximal apertures and distal apertures; a lumen extending through the lead body; electrodes at a distal portion of the lead body and connector interfaces at a proximal portion of the lead body; conductors extending through the lead body, with their proximal ends exiting via respective proximal apertures to couple with a respective connector interfaces, and their distal ends exiting the interior of the lead body via respective distal apertures to couple with a respective electrodes; and an electrically nonconductive filler element for occupying gaps in the interior of the lead body resulting from the exit of conductors from the lead body.

Neurostimulation leads with reduced current leakage

A system and method for locating and guiding a peripheral nerve evaluation (PNE) lead. The system comprising an X-ray system to capture images of the patient. The images are processed by the system and are provided to a user to utilize a measurement device for inserting a needle for placing leads for the PNE procedure.

System and method for placement of neurostimulation leads

Methods and systems for obtaining and analyzing electromyography responses of electrodes of an implanted neurostimulation lead for use neurostimulation programming are provided herein. System setups for neural localization and/or programming include a clinician programmer coupleable with a temporary or permanent lead implantable in a patient and at least one pair of EMG sensing electrodes minimally invasively positioned on a skin surface or within the patient. The clinician programmer is configured to determine a plurality of recommended electrode configurations based on thresholds and EMG responses of the plurality of electrodes and rank the electrode configuration according to pre-determined criteria. The clinician programmer further includes graphical user interface on which the plurality of recommended electrode configurations are displayed for modification and/or selection by a clinician in programming an IPG or EPG coupled with the lead to apply a neurostimulation treatment according to the selected electrode configuration.

Methods for determining neurostimulation electrode configurations based on neural localization

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region.

Electromyographic lead positioning and stimulation titration in a nerve stimulation system for treatment of overactive bladder

Methods for transcutaneous charging of an implanted device may include removably coupling a charging device with a carrier having adhesive tabs, the tabs being movable between a first position configured to be spaced away from a skin surface and a second position configured to be urged against the skin surface; engaging a bottom surface of the charging device at least partially against the skin surface with the tabs in the first position; positioning the charging device until it is at least partially positioned over or proximate the implanted medical device; and moving the tabs to the second position so that respective adhesive surfaces of the tabs contact and adhere to the skin of the patient sufficiently to support the charging device coupled with the carrier for a duration of time sufficient to charge the implanted device.

Attachment devices and associated methods of use with a nerve stimulation charging device

Implantable pulse generator external charger

A neurostimulation system having an external or an implantable pulse generator programmed to innervate a specific nerve or group of nerves in a patient through an electrode as a mode of treatment, having a patient remote that wirelessly communicates with the pulse generator to increase stimulation, decrease stimulation, and provide indications to a patient regarding the status of the neurostimulation system. The patient remote can allow for adjustment of stimulation power within a clinically effective range and for turning on and turning off the pulse generator. The patient remote and neurostimulation system can also store a stimulation level when the pulse generator is turned off and automatically restore the pulse generator to the stored stimulation level when the pulse generator is turned on.

Patient remote and associated methods of use with a nerve stimulation system

A clinician programmer may be coupled with an implantable temporary or permanent lead in a patient. Generally, the clinician programmer may comprise a portable housing, a signal/stimulation generator, and a graphical user interface. The housing has an external surface and encloses circuitry at least partially disposed within the housing. The signal/stimulation generator may be disposed within the housing and configured to deliver test stimulation to a nerve tissue of the patient via the implantable lead. The graphical user interface at least partially comprises the external surface of the housing and has a touch screen display for direct user interaction or for use with a keyboard, mouse, or the like.

Clinician programmer for use with an implantable neurostimulation lead

The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.

Percutaneous ports with wire coils

A hermetically sealed biocompatible pressure sensor module configured for implant at a desired site at which a pressure is to be measured. Anodic bonding of the pressure module package components which have similar thermal coefficients of expansion provides low stress bonding and maintains long term reliability, dependability and accuracy. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. Operating power for the pressure sensor module is provided by the external controller and an internal rechargeable energy storage component. Accordingly, the pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system. An exemplary use of the pressure sensor module is in a three pressure sensor system including a flow control valve in a shunt to treat hydrocephalus. The use of integrated circuit chips and an internal coil with an optional ferrite core in the pressure sensor module provides for low power consumption and reliable signal processing. An embodiment of the invention includes a pressure sensor and associated electromagnetic coils embedded in the tip portion of the shunt for measuring the pressure of fluid externally of the shunt at the tip portion.

Implantable shunt system and associated pressure sensors

Devices, systems and methods for transcutaneous charging of implanted medical devices are provided herein. Such devices include a portable charging device and an attachment device for affixing the portable charging device to a skin of the patient in a suitable location and alignment over the implanted medical device to facilitate charging. The attachment device can include a frame having an opening through which the charging device is mounted and one or more tabs extending laterally from the opening, each tab including an adhesive surface and being movable from a first position extending away from a skin of the patient to facilitate positioning of the charging device and a second position extending toward the skin of the patient so as to engage the skin of the patient and affix the charging device to the patient after being properly positioned.

Growing community of inventors

Irvine, CA, United States of America

Guangqiang Jiang