China Pharmaceutical University

Guangji Wang

Hong Wang

Haiping Hao

Jiyu Zhou

Shuang Cui

Xiaojie Pan

Yitong Guo

Ningning Huang

A composition containing SUMO inhibitor, and belongs to the technical field of medicine includes FXR agonist and SUMO inhibitor. In activated hepatic stellate cells, the FXR agonist does not have an effect in inhibiting the activation of hepatic stellate cells. After the FXR agonist and the SUMO inhibitor are compounded according to the present invention, the activation of hepatic stellate cells can also be inhibited for those cells under activated state. Of note, the hepatic stellate cells of an individual with hepatic fibrosis symptoms have been in an activated state, therefore a good anti-fibrotic effect cannot be achieved by using the FXR agonist alone.

Composition containing sumo inhibitor and application

Growing community of inventors

Nanjing, China

Guangji Wang