Shenyang Sunshine Pharmaceutical Co. Ltd.

Guangfeng Wang

Yunlong Zhou

Yu Jing

Ming Guo

Lingling Jiao

Suixiong Cai

Ping Min

A compound of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein Rand Rare independently H; Ris selected from H, a C-Cstraight-chain, and a branched or cyclic alkyl; and R, R, R, R, and Rare each independently selected from C-Calkyl, halo C-Calkyl and the like. Also provided is a method for preparing the compound, pharmaceutical compositions including the compound or pharmaceutically acceptable salts thereof, and uses of the compound or pharmaceutically acceptable salt thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO. 

Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof

A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided. In particular, the compound has the following Formula (I), wherein Rand Rare each independently H; Ris H or C-Calkyl; Ar is an aromatic ring or a heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. Pharmaceutically acceptable salts of the present compound, are provided, as well as uses of the compound or pharmaceutically acceptable salts thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO. 

Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof

Disclosed are a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, a preparation method thereof, pharmaceutical compositions and uses thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO, wherein in the formula (I), Rand Rare each independently hydrogen; Ris hydrogen or Calkyl; and Ar is an aromatic ring or an heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. 

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Shanghai, China

Guangfeng Wang