Sloan-Kettering Institute for Cancer Research

Memorial Sloan Kettering Cancer Center

Guangbin Yang

Ouathek Ouerfelli

Anna Dilhas

Hong Zhao

Sarah M Cheal

Steven M Larson

Michael R McDevitt

Steve Larson

Michael Mcdevitt

The present disclosure provides compositions and methods for the detection and treatment of cancer. Specifically, the compositions of the present technology include novel DOTA-haptens that may be complexed with a radioisotope (e.g.,Ac). Also disclosed herein are methods of the using the DOTA-haptens of the present technology in diagnostic imaging as well as pretargeted radioimmunotherapy.

Dota-hapten compositions for anti-dota/anti-tumor antigen bispecific antibody pretargeted radioimmunotherapy

The present disclosure provides compositions and methods for the treatment of cancer. Specifically, the compositions of the present technology include novel clearing agents that may be used in pretargeted radioimmunotherapy.

N-acetylgalactosamino dendron-clearing agent for dota-pretargeted radioimmunotherapy

A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

Synthesis of thiohydantoins

Growing community of inventors

Forest Hills, NY, United States of America

Guangbin Yang