Southeast University

Nanjing Luyesike Pharmaceutical Co., Ltd.

Jiangsu Provincial Institute of Materia Medica Co., Ltd.

Nanjing Zhenzhong Bioengineering Co., Ltd.

Nanjing Luye Pharmaceutical Co., Ltd.

Nanjing Asec Nano Biomedicine Co., Ltd.

Guang Cheng

Jinfeng Chen

Shengtao Yuan

Aihua Zhang

Yipeng Shen

Ancheng Ji

Pei Yuan Cheng

Jing Weng

Yi Gong Fang

Hua Wu

Xiaoyan Hu

A method for detecting slow HTTP DoS (SHD) attacks in a backbone network can detect three different types of SHID attacks. The method is divided into an off-line training phase and an on-line detection phase. In the off-line training phase, several types of representative unidirectional traffic features are extracted according to attack characteristics of different SHD types and corresponding feature groups are built, where these features can effectively deal with a large amount of unidirectional traffic in backbone networks; a public backbone network dataset is systematically sampled and data are stored in combination with Count-min Sketch, which greatly minimizes storage and computational overhead required in the backbone networks; and a specific machine learning algorithm is used for training to obtain attack detection models. The method can be used for detecting and warning SHD attacks in mass traffic scenarios such as backbone networks to provide a basis for maintaining network security.

Method for detecting slow HTTP DoS in backbone network

This present invention discloses a heterocyclic substituted acardite derivate and application thereof, namely compounds in the general formula (1) or the general formula (2) or pharmaceutically acceptable salts thereof, wherein A is monosubstituted or polysubstituted quinoline, isoquinoline, quinazoline, pyrrole or pyrimidine, and the substituent is halogen, Calkyl, Chaloalkyl, Calkoxy, Chaloalkoxy, Calkylamino, Chaloalkylamino, amino or nitryl; Ris Calkyl; Ris one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy; and Ris one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy. The compound of the present invention and the pharmaceutically acceptable salt thereof can be used for treating tumor or leukemia. 

Heterocyclic substituted acardite derivate and application thereof

The present invention discloses an antineoplastic sterile lyophilized powder of lentinan and the process of preparation thereof. The lyophilized powder of lentinan is essentially consisted of 0.50&#x2013;1.40 parts of lentinan and 50&#x2013;140 parts of excipient for lyophilization, based on weight. It has good stability. It has improved safety as it does not contain dextran which may cause allergic side effect.

Lyophilized powder of lentinan and the process of preparation thereof

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Jiangsu, China

Guang Cheng