Capitalbio Corporation

Tsinghua University

Capitalbio Technology Corporation

Capitalbio Technoloogy Corporation

Guanbin Zhang

Jing Cheng

Cheng Chen

Wanli Xing

Yuan Xue

Kaijun Zhao

Guangxin Xiang

Yang Li

Di Jiang

Jing Chen

Jia Wang

Tao Guo

Yu Dong

Tao Sheng

Shuang An

A method for labeling target molecules coupled to particles for the detection of the target molecules using a microarray chip, comprises: providing a functionalized microparticle, wherein the microparticle is coated with one or more functional group; providing a modification group on each of the target molecules to be detected to form modified target molecules; contacting the functionalized microparticle with the modified target molecules; coupling a luminophore to the complex between the functionalized microparticle and the modified target molecules, thereby directly or indirectly labeling each modified target molecules with the luminophore. By directly or indirectly labeling the target molecules with the luminophore, the method reduces the cost of fluorescence detection, and avoids PCR inhibition derived from traditional fluorescence labeling molecules.

Luminophore-labeled molecules coupled with particles for microarray-based assays

In some aspects, the present disclosure relates to a method for identifying the type of the unit by camera.

Method for identifying a unit using a camera

In some aspects, the present disclosure provides a biochip detecting device that comprises a first shell () connect to a second shell (), and a rotatable support frame () of biochip possessing a detecting zone that holds one or more biochips, and a detector ().

Device for detecting and/or analyzing bio-chip

The present disclosure provides a cover sheet for a microarray reaction device. In one aspect, the present cover sheet or device ensures the reaction units/volumes are stable and/or consistent among assay samples and assay runs, allowing samples (e.g., reaction solutions) to be conveniently added and distributed uniformly.

Micro-reactor array

The present disclosure relates to a method for camera identification and detection on color features. In some aspects, the method comprises: 1) starting the camera, the image processing unit and the display unit at the beginning of testing; 2) using the camera to capture the color characteristic value; and 3) moving the untested object to the detection area of the camera for it to be detected, wherein the image processing unit extracts the mean color characteristic value from the color pixels of the detection area.

Method for monitoring, identification, and/or detection using a camera based on a color feature

A microarray-based assay is provided, which is used for analyzing molecular interactions, including polynucleotides, polypeptides, antibodies, small molecule compounds, peptides and carbohydrates. Such method comprises coupling a target molecule to a particle and then binding to a probe molecule on microarray. In particular, multiplexed genetic analysis of nucleic acid fragments can be implemented. Specific genes, single nucleotide polymorphisms or gene mutations, such as deletions, insertions, and indels, can be identified. Coupled with microarray, the particles, themselves or further modified, facilitate the detection of results with non-expensive devices or even naked eyes. This technology enables the detection and interpretation of molecular interactions in an efficient and cost effective way.

Microarray-based assay integrated with particles for analyzing molecular interactions

Growing community of inventors

Beijing, China

Guanbin Zhang