Micron Technology Incorporated

Nhwa Pharma. Corporation

Topharman Shandong Co., Ltd.

Chinese Academy of Sciences

Topharman Shanghai Co., Ltd.

Ancureall Pharmaceutical (shanghai) Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Shanghai Institute of Pharmaceutical Industry

Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Suzhou Vigonvita Life Sciences Co., Ltd.

Genomicare Biotechnology (shanghai) Co. Ltd

Shanhai Institute of Pharmaceutical Industry

Guan Zhong Wang

Zhao Cui

Giuseppe D'Eliseo

Zheng Liu

Xinghui Duan

Eric Kwok Fung Yuen

Jianqi Li

Guisen Zhang

Xiangqing Xu

Rongxia Zhang

Weiming Chen

Jingshan Shen

Giuseppe Ferrari

Guanghui Tian

Xiangrui Jiang

Jutong Si

Meifeng Jiang

Shicheng Liu

Xiangping Yang

Yanqin Ma

Zhihe Yang

Chentao Zhou

Lin Guo

Hua Chen Li

Qiang Li

Yu Ying Wang

Hualiang Jiang

Xu Zhang

Yuan Yuan Zhang

Xin Xu

Zhen Wang

Xing Wang

Fan Yang

Zhen Zhang

Yang He

Jianfeng Li

Jia Chen

Yunfei Li

Qiang Xu

Jian Ge

Yijin Wang

Minquan Yu

Junjun Wang

Yali Li

Song Zhao

Huachen Li

Chunhui Wu

Yongjian Liu

Fuqiang Zhu

Xiaojuan Zhang

Tian Liang

Xiaowen Chen

Xiaoer Xia

Linli Zhang

Xianguo Zhao

Xudong Gong

Feipu Yang

Shixia Zhou

Chun Dai

Chenghao Xi

Chunqiao Chen

Minkai Qu

Yu Wang

Benpo Xu

Minghao Bi

Jingjing Yin

Xiaoguang Kong

Peng Xie

Linjie Zhang

Yumei Wang

Wenhua Ji

Shuming Hu

Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.

JAK kinase inhibitor, preparation method for same, and applications thereof in field of medicine

Methods, systems, and devices for unmap backlog in a memory system are described. A memory system may be configured to support receiving an unmap command from a host system and signaling, to the host system, an indication that the unmap command has been processed (e.g., handled, acknowledged). In response to the unmap command, the memory system may proceed with various unmap operations, which may include unmapping at least some of the associated addresses after indicating that the unmap command has been processed. For example, a memory system may implement an unmap backlog table to identify sections of addresses that are to be unmapped (e.g., after indicating that the unmap command has been processed). In some examples, the memory system may support various aspects of prioritization between unmap operations (e.g., background unmap operations) and other access operations such as read operations, write operations, or other access operations.

Unmap backlog in a memory system

Devices and techniques for variable width superblock addressing are described herein. A superblock width, specified in number of planes, is obtained. A superblock entry is created in a translation table of a NAND device. Here, the superblock entry may include a set of blocks, from the NAND device, that have the same block indexes across multiple die of the NAND device. The number of unique block indexes are equal to the number of planes and in different planes. A request, received from a requesting entity, is performed using the superblock entry. Performing the request includes providing a single instruction to multiple die of the NAND device and multiple data segments. Here, a data segment corresponds to a block in the set of blocks specified by a tuple of block index and die. A result of the request is then returned to the requesting entity.

Variable width superblock addressing

Devices and techniques for synchronizing NAND logical-to-physical table region tracking are described herein. Table region data structures for physical blocks are maintained. These structures include logical-to-physical (L2P) mapping table portions that point to the respective physical blocks. When garbage collection is performed on a block, table region structures for that block, and another (e.g., the next block to be garbage collected) are read to avoid loading L2P table regions that do not point to the block. If any of the read portions of the L2P table region fail to point to either the block or the other block, these L2P table portions are removed from the loaded table region data structures.

Synchronizing NAND logical-to-physical table region tracking

The invention relates to a histone methyltransferase EZH2 inhibitor, a preparation method and pharmaceutical use thereof. In particular, the invention relates to a compound represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the same, and a use thereof as a histone methyltransferase EZH2 inhibitor for treating diseases associated with the histone methyltransferase EZH2, especially cancer. The definition of each substituents in the general formula (I) is same as the definition in the specification. 

Histone methyltransferase EZH2 inhibitor, preparation method and pharmaceutical use thereof

Disclosed are for monitoring tumor load in a patient by selecting a predetermined number of biomarker genes from DNA extracted from a tumor tissue sample from the patient to form a panel of biomarker genes ('customized genes'); isolating circulating cell-free DNA from a bodily fluid (body fluid) sample of the patient; enriching DNA sequences containing the biomarker genes in the cell-free DNA fragments; sequencing the enriched DNA; counting the number of mutated DNA and normal DNA sequencing reads in enriched DNA; and obtaining a tumor load of the patient. Optionally, the detection of mutations in genes related to therapeutic treatments ('medicine genes') are carried out simultaneously with the testing of customized genes.

Systems and methods for monitoring lifelong tumor evolution field of invention

Disclosed in the present invention are an acrylanilide compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. The acrylanilide compound and the pharmaceutically acceptable salt thereof are used for treating clinical diseases by mainly acting on EGFR family casein kinases.

Acrylanilide derivative, preparation method, and applications thereof in pharmacy

The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease. 

Heterocyclic compounds, process for preparation of the same and use thereof

This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application. 

(2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone and preparation method and use thereof

Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range. The 3-cyanoanilinoalkylarylpiperazine derivative is a compound shown as formula (III) or free base or salt thereof: 

3-cyanoanilinoalkylarylpiperazine derivative and use thereof in preparing drugs

Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof.

Process for preparing racemic nicotine

The invention relates to a substituted phenylpiperazine aryl alkanol derivative represented by the following general formula and its salt and hydrate, wherein Cand Crepresent chiral carbon atoms, and the compound is one of the six isomers: (1RS, 2SR), (1RS, 2RS), (1R, 2S), (1S, 2S), (1R, 2R) or (1S, 2R); and R, R, R, Rand Ar are as defined in the specification. The derivative is non-opioid analgesic, has good analgesic effect and relatively small side effects. The invention also relates to a composition comprising the derivative and its use.

Substituted phenylpiperazinyl aralkylalcohol derivatives, pharmaceutical compositions containing such derivatives and uses thereof

The present invention relates to aralkyl piperidine derivatives, compositions containing the same, and their uses in the preparation of antalgic or ataractic medicament. The said derivatives are a free base of the compound represented by the following formula or a salt thereof. The pharmacological experiments show that they display favorable antalgic, ataractic activity and low side effects. 

Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent

Growing community of inventors

Shanghai, China

Guan Zhong Wang