Hawaii Biotech, Inc.

Panthera Biopharma LLC

Other

Guan-Sheng Jiao

Alan Thomas Johnson

Seong Jin Kim

Sean O'Malley

Seongjin Kim

Alan T Johnson

Compounds of formula I are provided: wherein X is NH, or CH, Y is a single bond, or &#x2014;CHR&#x2014;, Ris H, C-Calkyl, or C-Chydroxyalkyl, Rand R' are each independently H, C-Calkyl, or C-Chydroxyalkyl, each Ris independently H, halo, &#x2014;CF, C-Calkyl, or C-Calkoxy, Cperhaloalkyl, each Ris independently H, halo, or C-Calkyl, Ris C-Calkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.

Pyridin-2-yl alkylamino substituted hydroxamic acid and uses thereof

Compounds of Formula I are provided: Ris &#x2014;OR, m is an integer from 0 to 5, n is an integer from 0 to 2, each Ris independently selected from hydrogen, halogen, and alkyl, Ris selected from hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkylaminoalkyl, and heterocycloalkyl, Ris an alkyl, each Ris independently hydrogen or alkyl, and each of R, R, R, and Ris independently optionally substituted. Compounds of Formula I are included in pharmaceutical compositions for the treatment of a subject exposed to atoxin.

Hydroxamic acids comprising pyrazole moiety and uses thereof

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of aniline and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of phenoxy-acetic acids and analogs capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3-phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

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Honolulu, HI, United States of America

Guan-Sheng Jiao