Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Gu/ Nther Schmidt

Wolfgang Eberlein

Wolfhard Engel

Rudolf Hammer

Piero Del Soldato

Gu/ Nter Trummlitz

Gu/ Nther Trummlitz

Piero D Soldato

New pyridobenzodiazepinones of the formula ##STR1## are described wherein X represents oxygen, --NH-- or --NCH.sub.3 -- and R represents 1-methyl-4-piperidinyl or 4-methyl-1-piperazinyl group optionally substituted by a methyl group, or a 3.alpha.- or 3.beta.-tropanyl group, and the nontoxic pharmaceutically acceptable acid addition salts thereof. The specification also describes processes for preparing these compounds, pharmaceutical compositions containing these compounds and new intermediate products used in preparing them. The compounds of formula I have antiulcerative effects and an inhibitory effect on gastric acid secretion, without the side effects such as dryness of the mouth and mydriasis which occur with other substances having an anticholinergic activity.

Pyridobenzodiazepinones, pharmaceutical compositions and method of use

This invention relates to compounds of the formula ##STR1## wherein R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1-methyl-1,2,5,6-tetrahydro-4-pyridinyl, (1-methyl-4-piperidinylidene)methyl, 2,3-dehydro-8-methyl-8-azabicyclo�3.2.1!oct-3-yl methyl, endo-8-methyl-8-azabicyclo�3.2.1!oct-3-yl-methyl, or exo-8-methyl-8-azabicyclo�3.2.1!oct-3-yl-methyl, each of which may optionally have one or two methyl substituents on the six-membered heterocyclic ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.

Pyridobenzodiazepinones, pharmaceutical compositions thereof and method

This invention relates to novel compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms;

Thienobenzodiazepinones, pharmaceutical compositions thereof and method

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Biberach, Germany

Gu/ Nther Schmidt