Dr. Karl Thomae Gmbh

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Wolfgang Eberlein

Wolfhard Engel

Piero Del Soldato

Rudolf Hammer

Gu/ Nther Schmidt

Gerhard Mihm

Antonio Giachetti

There are described (+)-6-chloro-5,10-dihydro-5-[(1-methyl-4-piperidinyl)-acetyl]-11H-dibenzo [b,e][1,4]diazepin-11-one, the isolation thereof from a mixture of enantiomers and its use as a pharmaceutical material. The compound is characterized by a powerful activity against ulcers of the gastro-intestinal tract.

(+)-6-chloro-5,10-dihy

This invention relates to compounds of the formula ##STR1## wherein R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1-methyl-1,2,5,6-tetrahydro-4-pyridinyl, (1-methyl-4-piperidinylidene)methyl, 2,3-dehydro-8-methyl-8-azabicyclo�3.2.1!oct-3-yl methyl, endo-8-methyl-8-azabicyclo�3.2.1!oct-3-yl-methyl, or exo-8-methyl-8-azabicyclo�3.2.1!oct-3-yl-methyl, each of which may optionally have one or two methyl substituents on the six-membered heterocyclic ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.

Pyridobenzodiazepinones, pharmaceutical compositions thereof and method

This invention relates to novel compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms;

Thienobenzodiazepinones, pharmaceutical compositions thereof and method

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Warthausen, Germany

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