Janssen Pharmaceutica Nv

Galapagos Nv

Grégory Louis Joseph Bar

Martin James Inglis Andrews

Mark Stuart Chambers

Wolfgang Schmidt

Kim Louise Hirst

Juha Andrew Clase

Giovanni Alessandro Tricarico

Olga Raquel Pinto Santos Oliveira Roussel

Paul John Edwards

Sébastien Laurent Xavier Martina

Hervé Van De Poël

Xueliang Tao

Brigitte Allart

Friedrich Erich Karl Kroll

Andrew Burritt

Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases

Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R, R, Rand Ras defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

Substituted triazolopyrazines useful for the treatment of degenerative and inflammatory diseases

Novel imidazolopyridine compounds are disclosed that have a formula represented by the following:  The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases

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Mechelen, Belgium

Grégory Louis Joseph Bar