Ecole Polytechnique Federale De Lausanne

Gtx Medical B.v.

Onward Medical N.v.

University of Minnesota

Uti Limited Partnership

Ecole Polytechnique Féderale De Lausanne (epfl)

Onward Medical B.v.

Ecole Polytechnique Federale De Lausanne (epfl) Epfl-tto

Grégoire Courtine

Silvestro Micera

Marco Capogrosso

Jocelyne Bloch

Nikolaus Wenger

Joachim Von Zitzewitz

Fabien Wagner

Karen Minassian

Vincent Delattre

Pavel Musienko

Edoardo Paoles

Miroslav Caban

Stephanie P Lacour

Bert Bakker

Fabien Sorin

Robin Demesmaeker

Eduardo Martin Moraud

Damien Ganty

Ivan Rusev Minev

Marco Bonizzato

Arthur Hirsch

Nathan Greiner

Aaron Phillips

Jordan Squair

Quentin Barraud

David Darrow

Jacobus Deckers

Egbertus Bakker

Sophie Wurth

Salif Komi

Emanuele Formento

Jörg LÖFFLER

Wei Yan

Inès Richard

The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.

System for neuromodulation

The present disclosure relates to a neuromodulation and/or neurostimulation system comprising at least the following components: at least one sensing unit, at least control unit, at least one stimulation unit, at least one Central Nervous System (CNS) stimulation module, at least one Peripheral Nervous System (PNS) stimulation module, wherein at least one of the components of the neuromodulation and/or neurostimulation system is implantable.

Neurostimulation system for central nervous stimulation (CNS) and peripheral nervous stimulation (PNS)

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

System for selective spatiotemporal stimulation of the spinal cord

Neurostimulation lead

The present disclosure relates to an active closed-loop medical system comprising at least one implantable medical device, at least one non-implanted component and at least a controller for controlling the implantable medical device, wherein the implantable medical device, the non-implanted component and the controller are connected for data exchange, wherein the implantable medical device, the non-implanted component and the controller forming in the active state a closed-loop system in such that the implantable medical device is controlled by the controller on the basis of the signals exchanged with the non-implanted component.

Active closed-loop medical system

A method produces a device adapted to be implanted into the human body for purposes such as neural stimulation, sensing or the like. The method includes: providing a stretchable layer or membrane of an insulating material; forming on the layer or membrane at least one stretchable conductive path; depositing at least one small bolus of a soft and conductive paste or material onto pre-defined areas or portions of the at least one conductive path, and inserting a first end portion of a conductive elementinto the at least one bolus of soft conductive paste or material. A second end portion of the conductive element opposite to the first end portion is not inserted into the at least one bolus.

Synthetic skin for recording and modulating physiological activities

The invention relates to the selective targeting of specific &#x3b1;2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the improvement of locomotion by targeting specific receptor subtypes can be achieved by stimulation of the &#x3b1;2c receptor subtype using an &#x3b1;2c specific agonist or by blocking the &#x3b1;2a receptor subtype using &#x3b1;2a antagonists. A combination of an &#x3b1;2c agonist and an &#x3b1;2a antagonist is also provided for a synergistic effect. Alternatively, a large &#x3b1;2 agonist can be used in combination with an &#x3b1;2a antagonist to achieve specific stimulation of the &#x3b1;2c receptor. Pharmaceutical compositions, kit-of-parts and therapeutic systems comprising said agonists/antagonists as active agents are objects of the present invention. A robotic interface and epidural electric stimulation can also be used in combination with the compositions of the invention for restoring voluntary control of locomotion.

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

Apparatus and method for restoring voluntary control of locomotion in neuromotor impairments

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising electrodes for applying to a subject neuromodulation with adjustable stimulation parameters, the electrodes being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with the electrodes said and providing the electrodes with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), a multiple input-single output (MISO) model, or a multiple input-multiple output (MIMO) model.

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

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Lausanne, Switzerland

Grégoire Courtine