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Grigory N Pershin

Anatoly B Davydov

Sergei I Belykh

Anatoly D Moschensky

Gely G Pershin

Igor L Kovalenko

Elena N Padeiskaya

Lidia M Polukhina

Nikolai I Ochirov

Jury I Filippov

Lidia Y Loktionova

Alexei Nikolaevich Grinev

Jury Fedorovich Maichuk

Nadezhda Sergeevna Bogdanova

Irina Sergeevna Nikolaeva

Maxim Yakovlevich Kraft

Galina Yakovlevna Uretskaya

Teshabai Nazarovich Avazov

Roza Isaakovna Abramishvili

Svetlana Jurievna Anikina

According to the present invention there is provided a joining element for fixation of bone tissues, which is made essentially as an oblong solid provided with recesses, wherein are made fast inserts of a biologically compatible polymer, containing a physiologically active medical preparations.

Joining element for fixation of bone tissues

According to the present invention there is provided a joining element for fixing bone tissues, which is made essentially as an oblong solid provided with recesses, wherein are made fast inserts of a biologically compatible polymer, containing a physiologically active medical preparations.

A medicinal preparation for treatment of viral-etiology diseases contains the bisulphite compound of 2-fluorenonyl-glyoxal in combination with a pharmaceutical vehicle or unctuous base. A method of producing the bisulphite compound of 2-fluorenonyl-glyoxal, viz, the active principle of said medicinal preparation, consists in that fluorene is acylated by dichloroacetyl chloride in the presence of aluminum chloride and phosphoryl chloride in an organic solvent, the resultant 2-.omega.-dichloroacetylfluorene is oxidized by the salts of chromic acid in an acetic-acid medium at 50.degree.-90.degree. C into 2-.omega.-dichloroacetylfluorenone which is made to interact with morpholine at 50.degree.-98.degree. C to form 2-.omega.-dimorpholinoacetylflourenone, or otherwise, fluorenone is acylated by acetic anhydride in an organic solvent in the presence of aluminum chloride, the resultant 2-acetylfluorene is oxidized by chromic acid or by the salts thereof in an acetic acid medium at 50.degree.-90.degree. C to obtain 2-acetylfluorenone which is brominated in an organic solvent at 60.degree.-110.degree. C, the resultant 2-.omega.-dibromoacetylfluorenone is reacted with morpholine at 50.degree.-98.degree. C to form 2-.omega.-dimorpholinoacetylfluorenone the latter is hydrolyzed by dilute mineral acids at 20.degree.-100.degree. C into 2-fluorenonyl-glyoxal hydrate which is then made to react with sodium bisulphite in an aqueous-alcohol medium at 60.degree.-80.degree. C to isolate the final product.

Medicinal preparation for treatment of viral-etiology diseases

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Moscow, Russia

Grigory N Pershin