Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Vsesojuzny Kardiologichesky Nauchny Tsentr

Grigory M Grinberg

Evgeny I Chazov

Vladimir N Smirnov

Vladimir P Torchilin

Oleg N Akifiev

Agris Z Skuya

Anatoly P Gilev

Jury A Pytel

Boris V Moskvichev

Monika Y Paberza

Igor M Tereshin

Gersh I Kleiner

Disclosed is an antibacterial pharmaceutical composition comprising potasm salt of N-[.beta.-(5'-nitrofuryl-2')-acrylidene]-1-aminohydantoin and basic magnesium carbonate in conjunction with a pharmaceutically suitable filler. The proposed antibacterial pharmaceutical composition has a broader spectrum of action and a higher biological accessibility than the other antibacterial pharmaceutical compositions of the nitrofuran series known in the prior art. The proposed pharmaceutical composition is considerably less toxic than the prior-art antibacterial pharmaceutical compositions of the nitrofuran series and affords a bacteriostatic effect exceeding appreciably that of the prior-art antibacterial pharmaceutical compositions of the nitrofuran series.

Antibacterial pharmaceutical composition

A method of preparing a polysaccharide derivative of fibrinolysin which comprises reacting fibrinolysin with dextran dialdehyde having a molecular mass of from 20,000 to 110,000 at a pH of from 8.0 to 9.5 and at a temperature within the range of from 5.degree. to 30.degree. C. with the formation of a covalent bond; the resulting fibrinolysin derivative is reduced with sodium borohydride and isolated.

Dextran derivative of fibrinolysin

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Moscow, Russia

Grigory M Grinberg