Rijksuniversiteit Te Groningen

Synvolux IP B.v.

Grietje Molema

Dirk Klaas Meijer

Rudi Wilfried Pauwels

Robert Walter Jansen

Marcel Herman Ruiters

Dominique Schols

Erik Desire De Clercq

Joanna Ewa Adrian

Johannes Adrianus Antonius Maria Kamps

Marcel Herman Josef Ruiters

Johannes Adrianus Kamps

The invention relates to pharmaceutical preparations which are suitable for treating viral infections, including influenza and immunodeficiency diseases and which can also be used in vitro, to inhibit fusion of virus-infected cells with non-infected cells, which preparations contain modified proteins or polypeptides as active substance or substance contributing to the action or as carrier for other substances, which are also active, which modified proteins or polypeptides have acquired an additional net negative charge by derivatisation of their amino groups and/or other basic functional groups with aconitic acid which prevents protonation of basic amino acids and/or other basic functional groups or replaces basic amino acids and/or other basic functional groups by one or more functional groups having a negative charge, and to modified proteins and polypeptides themselves and their preparation and use.

Modified proteins and their use for controlling viral infections

Growing community of inventors

Groningen, Netherlands

Grietje Molema