Ascendis Pharma Endocrinology Division A/s

Ascendis Pharma Growth Disorders Division A/s

Ascendis Pharma Endocrinology Division

Grethe Nørskov Rasmussen

Harald Rau

Ulrich Hersel

Thomas Wegge

Susanne Kindermann

Joachim Zettler

Torben Lessmann

Steen Jensen

Alina Hermann

Nina Schubert

Evelyn Exner

Thomas Kurpiers

Anna Splanemann

Kennett SprogØe

Kennett Sprogøe

The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.

Dry growth hormone composition transiently linked to a polymer carrier

The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulation comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

Polymeric hGH prodrugs

The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8&#xb0; C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.

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Farum, Denmark

Grethe Nørskov Rasmussen