Teva Pharmaceutical Industries Limited

Teva Pharmaceuticals Usa, Inc.

Other

Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Greta Sterimbaum

Valerie Niddam-Hildesheim

Shlomit Wizel

Ehud Amir

Tamas Koltai

Maytal Piran

Sigalit Levi

Evgeny Shapiro

Kobi Chen

Hagit Eisen-Nevo

Adi Yeori

David Malcolm Crowe

Shay Asis

Ben-Zion Dolitzky

Claude Singer

Csaba Szabo

Gideon Pilarski

Ronit Yahalomi

Lorant Gyuricza

Szabolcs Szoke

Crystalline forms of Nilotinib HCl are described.

Nilotinib HCl crystalline forms

The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard.

Purification of montelukast

Provided is a process for preparation of amorphous form of an active pharmaceutical ingredient.

Process for preparation of amorphous form of a drug

The present invention provides processes for preparing montelukast.

Processes for preparing montelukast sodium

Provided are a method for making (&#xb1;)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolenecarboxylic acid, commonly known as gatifloxacin, in high purity, in a suspension in a dipolar aprotic solvent.

Synthesis of gatifloxacin

Provided are novel crystalline forms of gatifloxacin denominated forms A, B, C, D, E1, F, G, H, I, and J, and methods for their preparation. Also provided are methods for making known crystalline forms of gatifloxacin, in particular forms omega and T2RP.

Crystalline forms of gatifloxacin

Provided are two novel crystalline forms of gatifloxacin, denominated form O and form V, and methods for their preparation.

Provided are novel crystalline forms of gatifloxacin, denominated forms L, M, P, Q, S, and T1, and methods for making them. Also provided are methods of transforming the novel crystalline forms of gatifloxacin of the present invention to other crystalline forms of gatifloxacin.

The present invention provides processes for preparing calcium salts of statin, particularly rosuvastatin calcium salt substantially free of impurities on an industrial scale.

Process for preparation of rosuvastatin calcium

Provided are novel crystalline forms of gatifloxacin, some of which are DMSO solvates, and methods for making them.

Growing community of inventors

Rishon-LeZion, Israel

Greta Sterimbaum