Pfizer Corporation

Gregory Wayne Kauffman

Patrick Robert Verhoest

Michael Eric Green

Martin Youngjin Pettersson

Douglas Scott Johnson

Antonia Friederike Stepan

Christopher William Am Ende

Chakrapani Subramanyam

Christopher John O'Donnell

Nandini Chaturbhai Patel

Tuan Phong Tran

Cory Michael Stiff

Michael Aaron Brodney

Bruce Nelsen Rogers

Scot Richard Mente

Justin Ian Montgomery

John Michael Humphrey

Christopher John O'donnell

Kapildev Kashmirilal Arora

Natasha Mariam Kablaoui

Danica Antonia Rankic

Matthew Francis Dunn

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R, R, R, R, R, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating kappa opioid (&#x3ba;-opioid) associated disorders including, e.g., a neurological disorder, or psychiatric disorder such as a neurocognitive disorder, substance abuse disorder, depressive disorder, anxiety disorder, trauma and stressor related disorder and feeding and eating disorder.

Heteroarylphenoxy benzamide kappa opioid ligands

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I wherein X, R, R, R, R, R, R, R, R, R, R, R, and y are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Cyclopropabenzofuranyl pyridopyrazinediones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders

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East Greenwich, RI, United States of America

Gregory Wayne Kauffman