Third Pole, Inc.

Baronova, Inc.

Zoll Circulation, Incorporated

Vascular Pathways, Inc.

Potrero Medical, Inc.

Velomedix, Inc.

Sequana Medical Ag

Sequana Medical Nv

Baxter Corporation Englewood

Revivant Corporation

Nektar Therapeutics

Gregory Walter Hall

Daniel Rogers Burnett

Wolfgang Scholz

David G Zapol

Benjamin Apollonio

Paul Quentin Escudero

Bob H Katz

Frank J Heirtzler

Ian J Gillerman

Amir Belson

Robert Brommer

Scott A Daniel

Andrew Ferencz

Jordan T Bajor

Timothy R Dalbec

Christopher Miles

Annette Campbell-White

Darren R Sherman

Paul B Guerra

David A Gallup

Roxanne Richman

Tibor Laszlo Hites

Philip E Silkoff

Ziad F Elghazzawi

Adrian Edward Smith

Brian M Neil

Charles E Swinehart

Reynaldo J Quintana

William W Alston

James O Jensen

Byron Reynolds

Winfield Scott Fisher

Amit Rajguru

Adam Young

Christopher Hermanson

Daniel R Burnett

Aubrey Ortiz

Sina Mohsenian

James Anthony McCrea

Michael Dickson Olichney

Brian William Ward

Roy Sven Hovland

Tammy Stultz

James Robert Hutchison

Stephen Norman Donnigan

Jeffery Jonathan Rau

Kevin Cedrone

Simon E Kozin

Vineel Kondiboyina

Sweta Patel

Steve K Kele

Walter Cecka

James Robert Hutchison Iii

James Mccrea

Tammy Lynn Stultz

Winfield Fisher

Gal Cohen

A method for accessing a blood vessel using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The thumbwheel is rotatably fastened at a front end of the housing and accessible through an opening in the housing. The guidewire is coupled to the thumbwheel such that an axis of rotation of the thumbwheel is perpendicular to the guidewire and rotation of the thumbwheel advances the guidewire through the lumen of the needle. The method includes preparing the catheter insertion device, inserting a tip of the needle and distal end of the catheter into a blood vessel, advancing the guidewire out of the lumen of the needle into the blood vessel by holding the housing and rotating the thumbwheel, furthering the distal end of the catheter over the guidewire, and removing the needle and the guidewire from the catheter.

Intravenous catheter insertion device and method of use

Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Systems and methods for delivering nitric oxide

A method for treating a patient using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The needle extends through the catheter such that a distal end of the needle extends distal of a distal end of the catheter. The guidewire is coupled to the thumbwheel such that rotation of the thumbwheel advances a distal end of the guidewire through a lumen of the needle. The method includes holding the catheter insertion device, inserting the distal end of the needle and catheter into a blood vessel, rotating the thumbwheel to advance the distal end of the guidewire out of the lumen of the needle into the blood vessel, moving the catheter over the guidewire in the blood vessel, and removing the needle and the guidewire from the catheter.

Intravenous catheter insertion device

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Systems and methods for ambulatory generation of nitric oxide

A device and methods for treating renal failure are disclosed. One embodiment of the device is an implantable peritoneal dialysis device. When in use, the device can have a semi-permeable reservoir implanted in the peritoneal cavity. The reservoir can receive blood waste and drain through one or more conduits, via a pump, to the biological bladder. Solids and/or a solution benefiting dialysis can be pumped to the reservoir and/or implanted in the peritoneal cavity.

Implantable fluid management system for treating heart failure

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NOgas analysis sensors without the use of a calibration gas.

Systems and methods for generating nitric oxide

System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.

Systems and methods for preventing and treating infections with nitric oxide

Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NOfrom the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Systems and methods for nitric oxide generation with humidity control

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Electrodes for nitric oxide generation

Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

Growing community of inventors

Redwood City, CA, United States of America

Gregory Walter Hall