Novartis Finance Corporation

Syngenta Participations Ag

Ciba-geigy Corporation

Syngenta Investment Corporation

Novartis Corporation

Syngenta Investments, Inc.

Gregory W Warren

Michael G Koziel

Nalini M Desai

Gordon J Nye

Vance Cary Kramer

Juan J Estruch

Martha A Mullins

Brian S Carr

Erik M Dunder

Martha S Wright

John L Dawson

Karen L Launis

Kristy Kostichka

Stephen V Evola

Gary M Pace

Frank Arthur Shotkoski

Kelly S Lewis

Janet L Suttie

Cindy G Bowman

Steven J Rothstein

Nicholas B Duck

Paul J Miles

Vance C Kramer

Shen Zhicheng

Nadine B Carozzi

Lyle Dean Crossland

Zhicheng Shen

Ellis J Merlin

Cao-Guo Yu

Moez Rajabali Meghji

Jeng Shong Chen

Hope Prim Hart

Annick Jeanne De Framond

Bruce Wayne Skillings

Arne Robert Anderson

Michael Kent Morgan

Annick J De Framond

Robert L Miller

James O Linder

Christopher P Clucas

Cindy Boyce

Steve Evola

Francis E Cassagne

Martha M Dunn

Alan W Mousel

Albert R Hornbrook

Andreas H Tanner

Gilles Pollini

Nadine G Carozzi

Terry Ray Colbert

Jan Suttie

Francis P Cammack

Frank Shotkoski

Zhicheng Morrisville North Carolina Shen

Nucleic acid molecules encoding novel Vip3 toxins that are highly active against a wide range of lepidopteran insect pests are disclosed. The nucleic acid molecules can be used to transform various prokaryotic and eukaryotic organisms to express the Vip3 toxins. These recombinant organisms can be used to control lepidopteran insects in various environments.

VIP3 toxins and methods of use

Vip3 toxins and methods of use

A novel pesticidal toxin that is highly active against a wide range of lepidopteran insect pests is disclosed. The DNA encoding the pesticidal toxin can be used to transform various prokaryotic and eukaryotic organisms to express the pesticidal toxin. These recombinant organisms can be used to control lepidopteran insects in various environments.

Pesticidal toxins

Expression and use of novel pesticidal toxins

A novel pesticidal toxin isolated fromthat is highly active against a wide range of lepidopteran insect pests is disclosed. The DNA encoding the pesticidal toxin can be used to transform various prokaryotic and eukaryotic organisms to express the pesticidal toxin. These recombinant organisms can be used to control lepidopteran insects in various environments.

Novel Vip3C toxins that are highly active against European corn borer and other lepidopteran insect pests are disclosed. The Vip3C toxins can be expressed in various prokaryotic and eukaryotic organisms including plants to control lepidopteran insects in various environments.

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from . Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

Transgenic maize seed and method for controlling insect pests

The genes encoding a novel class of insecticidal proteins have been isolated and characterized from a strain of . Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molecules are utilized in the transformation of host microorganisms and production of transgenic plants which are resistant to insects. Also, the gene encoding for the insect's receptor of the insecticidal protein has been isolated and characterized. Novel processes and methods for controlling plants pests are provided.

Plant pest control

Methods for transformation of maize with nucleic acid sequences of interest are disclosed. The method involves subjecting immature zygotic embryos or Type I callus to high velocity microprojectile bombardment. The method is capable of producing transformed maize lines of commercial importance and their hybrid combinations.

Method of producing transgenic maize using direct transformation of commercially important genotypes

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from,. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

Synthetic DNA sequences having enhanced insecticidal activity in maize

Novel nucleic acid sequences isolated from,whose expression results in novel insecticidal toxins, are disclosed herein. The invention also discloses compositions and formulations containing the insecticidal toxins that are capable of controlling insect pests. The invention is further drawn to methods of making the toxins and to methods of using the nucleotide sequences, for example in microorganisms to control insect pests or in transgenic plants to confer insect resistance.

Insecticidal toxins from Photorhabdus luminescens and nucleic acid sequences coding therefor

The genes encoding a novel class of insectecidal proteins have been isolated and characterized from a strain of Bacillus thuringiensis. Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molcules are utilized in the transformation of host microorganisms and production of trangenic plants which are resistant to insects. Also, the gene encoding for the insect's receptor of the insecticide protein has been isolated and characterized. Novel processes and methods for controlling plants pests are provided.

Class of proteins for the control of plant pests

The genes encoding a novel class of insecticidal proteins have been isolated and characterized from a strain of Bacillus thuringiensis. Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molecules are utilized in the transformation of host microorganisms and production of transgenic plants which are resistant to insects. Also, the gene encoding for the insect's receptor of the insecticidal protein has been isolated and characterized. Novel processes and methods for controlling plants pests are provided.

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

Synthetic DNA sequence having enhanced insecticidal activity in maize

Growing community of inventors

Cary, NC, United States of America

Gregory W Warren