R.p.scherer Technologies, Inc.

Redwood Bioscience, Inc.

Other

Gregory W deHart

David Rabuka

Jeanne E Baker

Patrick Holder

Robyn M Barfield

Albert W Garofalo

Aaron Edward Albers

Romas Alvydas Kudirka

Penelope M Drake

Jesse M McFarland

Mark Alan Breidenbach

The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Anti-HER2 antibody-maytansine conjugates and methods of use thereof

The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.

Activated formylglycine-generating enzymes and methods of producing and using the same

The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.

Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof

Growing community of inventors

El Cerrito, CA, United States of America

Gregory W deHart