Seer, Inc.

Prognomiq, Inc.

Pfizer Corporation

Gregory Troiano

John E Blume

Omid C Farokhzad

William Manning

Xiaoyan Zhao

Michael Figa

Abhimanyu Sabnis

Lyndal Hesterberg

Craig Stolarczyk

Theodore Platt

Hongwei Xia

Matthew McLean

Marwin Ko

Philip Ma

Asim Siddiqui

William C Manning, Jr

Hope Liou

Shadi Roshdiferdosi

This disclosure provides methods and compositions for biomolecule corona analysis of biofluids. A biofluid may be contacted with a nanoparticle to form a biomolecule corona, and the composition of the resulting corona may be analyzed. Also provided are methods of preparing a biofluid for corona analysis by serial interrogation.

Compositions, methods and systems for protein corona analysis and uses thereof

Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.

Disclosed herein are methods and compositions for processing biofluid samples. Some such methods may include obtaining a biofluid sample from a subject having a disease state such as lung cancer. The biofluid sample may be contacted with a nanoparticles to adsorb proteins. The proteins may then be ionized or contacted with a detection reagent. Also disclosed herein are compositions comprising proteins coupled to a nanoparticle upon contact of the nanoparticle with a biofluid sample from a subject having a disease.

Methods of processing a biofluid sample

Disclosed herein are biomarkers associated with a disease state such as lung cancer, and methods of discovering or using biomarkers. Also disclosed herein are classifiers built on biomarkers and methods of detecting the disease state in samples from subjects. The method may include obtaining a data set that includes protein information from a biofluid sample, and may involve using a classifier to identify the sample as indicative of a healthy state, a disease state, or a comorbidity.

Lung biomarkers and methods of use thereof

Growing community of inventors

Pembroke, MA, United States of America

Gregory Troiano