Genentech, Inc.

Laboratory Corporation of America Holdings

Other

Esoterix, Inc.

Gregory T Stelzer

Mark X Sliwkowski

Mary Beth Gardiner

Robert L Cohen

Norman B Purvis

Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.

Simultaneous assay of target and target-drug binding

Assay for analysis of free drug in samples

This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods.

Tissue analysis and kits therefor

This invention relates to methods of analyzing a tissue sample from a subject. In particular the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods.

Methods for tissue analysis

Growing community of inventors

Brentwood, TN, United States of America

Gregory T Stelzer