E.i. Dupont De Nemours and Company

Gregory T Bryan

Brian McGonigle

Carl A Maxwell

Barbara Sue Valent

This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.

Enzymes involved in triterpene synthesis

The preparation and use of an isolated nucleic acid fragment which confers a Pi-ta resistance gene-mediated defense response in plants against disease caused by fungal pathogens is described. Genes incorporating such nucleic acid fragments either alone or in combination with an AVR-Pita isolated nucleic acid fragment or functionally equivalent subfragments thereof and suitable regulatory sequences can be used to create transgenic plants which can produce a Pi-ta resistance gene-mediated defense response against a variety of fungal pathogens, in particular, the rice blast fungus.

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Wilmington, DE, United States of America

Gregory T Bryan