Cepheid Corporation

Nanogen, Inc.

Leland Stanford Junior University

Rochester Institute of Technology

Applied Cognition, Inc.

Defense Advanced Research Projects Agency

Other

Physiowave, Inc.

Gregory T A Kovacs

Kurt Edward Petersen

William A McMillan

M Allen Northrup

Lee Allan Christel

Ronald G Chang

Farzad Pourahmadi

Jesus Ching

Steven Jay Young

Douglas Bryan Dority

Laurent B Giovangrandi

Robert Allan Yuan

Jonathan I Kaplan

Gregory J Kintz

Jeffrey L Rogers

Raymond T Hebert

Joerg Christoph Student

David Borkholder

Paul Dagum

Carl J Weber

Nathan Whipple

Konstantin Othmer

David A Lee

Terence G Ryan

William A Mcmillan

Wm Leroy Heinrichs

David Salzberg

Leon G Partamian

R Hollis Whittington

Matthew Bloom

A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A function mapping is executed from said neurophysiological and neurovascular data to a target that is one of a glymphatic flow marker, a molecular analysis marker of neurodegeneration, or a neuroimaging marker of neurodegeneration. A target prediction model is output based on the function mapping. The target prediction model can receive new neurophysiological and neurovascular data and output a predicted marker of neurodegeneration.

Non-invasive assessment of glymphatic flow and neurodegeneration from a wearable device

A method including a dosimetry device having at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.

Event dosimeter device and methods thereof

A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.

Event dosimeter devices and methods thereof

An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.

Method for separating an analyte from a sample

A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.

Thermal cycler with optical detector

The present invention provides a sensitive system for measuring the physiological response of an in-vitro cell culture to an environmental parameter. An electrical property of the cell culture is measured as a control signal, and a parameter of a stimulus is adjusted in real time to maintain the control signal at a specified value as the environment of the cell culture is altered, for example, pharmacologically. Artifact reduction and real-time control methods are two key aspects of preferred embodiments of the invention, and enable highly accurate determination of pulse parameters which elicit a desired response. Both aspects must be highly robust to the natural variations inherent in a biological system. This system is beneficial for studying the effects of environmental alterations because extremely small changes in the physiological response can be measured over time, revealing the magnitude and time-dependence of the impact of these alterations on the cell culture.

Closed-loop electrical stimulation system for cell cultures

In some embodiments, a wearable physiologic monitor comprises an application-specific integrated circuit (ASIC) including signal conditioning circuitry, a real-time clock, digital control logic, and mode-selection logic for setting an operating mode of the ASIC to a stand-alone mode or a peripheral mode. In the stand-alone mode, the digital control logic periodically stores data packets including multiple sensor data types in a digital memory such as a removable flash memory card. In the peripheral mode, the data packets are transmitted to a microcontroller for processing. The monitor includes sensors such as electrocardiogram (ECG) electrodes, accelerometers, and a temperature sensor, some of which may be integrated on the ASIC. The same basic chip design may be used in the stand-alone mode in disposable patches, and in the peripheral mode in bedside devices. The operating mode may be chosen at monitor manufacture, by connecting input pins to mode-selection logic levels.

Dual-mode physiologic monitoring systems and methods

A method and apparatus for addressing and driving an electrode array includes addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.

Multiplexed active biologic array

Method for separating analyte from a sample

A method for making a plurality of low-cost microelectrode arrays (MEAs) on one substrate utilizing certain unmodified printed circuit board (PCB) fabrication processes and selected materials. In some embodiments, a MEA device is composed of a thin polymer substrate containing patterned conductive traces. Coverlays on both sides of the substrate insulate the conductive traces and defines the electrodes. Preferably, flexible PCB technology is utilized to simultaneously define the microelectrode arrays. In an embodiment, the sensor is an integrated temperature sensor/heater in which the MEA device operates to record extracellular electrical signals from electrically active cell cultures. The present invention enables economical and efficient mass production of MEA devices, making them particularly suitable for disposable applications such as drug discovery, biosensors, etc.

Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods

This invention provides an apparatus for rapidly heating and/or cooling a sample in a reaction vessel. In some embodiments, the apparatus includes optics for the efficient detection of a reaction product in the vessel. The invention also provides a reaction vessel having a reaction chamber designed for optimal thermal conductance and for efficient optical viewing of reaction products in the chamber.

Apparatus and reaction vessel for controlling the temperature of a sample

A system for controlling the temperature of a reaction mixture comprises at least one heating device for heating the mixture and a power regulator for regulating the amount of power supplied to the heating device. A controller in communication with the power regulator includes program instructions for heating the reaction mixture by setting a variable target temperature that initially exceeds a desired setpoint temperature for the mixture. When the heating device reaches a threshold temperature, the variable target temperature is decreased to the desired setpoint temperature. In another embodiment, the controller includes an adaptive control program for dynamically adjusting the duration or intensity of power pulses provided to the heating device.

System and method for temperature control

Growing community of inventors

Stanford, CA, United States of America

Gregory T A Kovacs