Wyeth

Elan Pharmaceuticals, Inc.

Other

American Home Products Corporation

Gregory Scott Welmaker

Eugene D Thorsett

Andrei William Konradi

Christopher Michael Semko

Susan Ashwell

Anthony Frank Kreft

Michael A Pleiss

Dimitrios Sarantakis

Darren B Dressen

Ying-Zi Xu

Francine S Grant

Annmarie Louise Sabb

Joan E Sabalski

James Albert Nelson

Sharon J Rosenzweig-Lipson

Robert Lewis Vogel

John Anthony Butera

Eugene John Trybulski

Michael D Smith

Matthew A Wilson

Christopher Joseph Soares

Kiev S Ly

Christine M Tarby

Frank Stappenbeck

Geraldine Ruth McFarlane

Ronald L Magolda

Francine S Farouz

David R Herbst

Robert Warren Sullivan

Michael A Pliess

Dimitrios Sarntakis

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4

Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Alpha amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4

The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.

Tetracyclic indoles as potassium channel modulators

Benzofurans as potassium ion channel modulators

This invention provides processes for preparing compounds formula: wherein R is H, alkyl, acyl, aryl, aroyl or &#x2014;C(O)R'; R&#x2032; is alkyl or aryl; R, R, Rand Rare H, &#x2014;OH, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl or alkoxy, &#x2014;CN, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, acyl, aryl or aroyl; Ris H, alkyl, cycloalkyl, alkoxy, fluorinated alkyl, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, aryl, or aroyl; or a pharmaceutically acceptable salt thereof, as well as novel compounds useful in the synthesis of these compounds.

Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives

Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.

Phenylalanine derivatives as alpha 4 integrin inhibitors

This invention provides compounds of the formulae: wherein:

Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4

Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives

This invention provides compounds of formula I, wherein

2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives

Disclosed are a series of heteroaryl-&#x3b2;-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.

Heteroaryl-&#x3b2;-alanine derivatives as alpha 4 integrin inhibitors

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Jackson, NJ, United States of America

Gregory Scott Welmaker